The association between diabetes medication and weight change in a non‐surgical weight management intervention: an intervention cohort study

Aldekhail, N.M., Morrison, D.S., Khojah, H., Sloan, B., McLoone, P. , MacNaughton, S., Shearer, R. and Logue, J. (2020) The association between diabetes medication and weight change in a non‐surgical weight management intervention: an intervention cohort study. Diabetic Medicine, 37(2), pp. 248-255. (doi: 10.1111/dme.14093) (PMID:31365143)

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Abstract

Aim: To compare weight change in a lifestyle‐based weight management programme between participants taking weight‐gaining, weight‐neutral/loss and mixed diabetes medications. Methods: Electronic health records for individuals (≥ 18 years) with Type 2 diabetes who had been referred to a non‐surgical weight management programme between February 2008 and May 2014 were studied. Diabetes medications were classified into three categories based on their effect on body weight. In this intervention cohort study, weight change was calculated for participants attending two or more sessions. Results: All 998 individuals who took oral diabetes medications and attended two or more sessions of weight management were included. Some 59.5% of participants were women, and participants had a mean BMI of 41.1 kg/m2 (women) and 40.2 kg/m2 (men). Of the diabetes medication combinations prescribed, 46.0% were weight‐neutral/loss, 41.3% mixed and 12.7% weight‐gaining. The mean weight change for participants on weight‐gaining and weight‐neutral/loss diabetes medications respectively was −2.5 kg [95% confidence interval (CI) −3.2 to −1.8) and −3.3 kg (95% CI −3.8 to −2.9) (P = 0.05) for those attending two or more sessions (n = 998). Compared with those prescribed weight‐neutral medications, participants prescribed weight‐gaining medication lost 0.86 kg less (95% CI 0.02 to 1.7; P = 0.045) in a model adjusted for age, sex, BMI and socio‐economic status. Conclusions: Participants on weight‐neutral/loss diabetes medications had a greater absolute weight loss within a weight management intervention compared with those on weight‐gaining medications. Diabetes medications should be reviewed ahead of planned weight‐loss interventions to help ensure maximal effectiveness of the intervention.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McLoone, Mr Philip and Morrison, Dr David and Logue, Dr Jennifer and Aldekhail, Nasser Mohammed N
Authors: Aldekhail, N.M., Morrison, D.S., Khojah, H., Sloan, B., McLoone, P., MacNaughton, S., Shearer, R., and Logue, J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Public Health
Journal Name:Diabetic Medicine
Publisher:Wiley
ISSN:0742-3071
ISSN (Online):1464-5491
Published Online:31 July 2019
First Published:First published in Diabetic Medicine 37(2):248-255
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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