Therapy adherence issues in Parkinson's disease

Grosset, D. (2010) Therapy adherence issues in Parkinson's disease. Journal of the Neurological Sciences, 289(1-2), pp. 115-118. (doi: 10.1016/j.jns.2009.08.053) (PMID:19793590)

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The response to dopamine replacement therapy in patients with degenerative parkinsonism is variable. Reasons for a poor therapy response include the type of parkinsonism, comorbidities, and differential effects on clinical features. An additional explanation, which has received much less attention, is sub-optimal therapy compliance. Single and multicentre studies of therapy compliance report significant under- and overuse of dopamine replacement therapy resulting in poor symptomatic control, or features of the dopamine dysregulation syndrome or other signs of dopaminergic excess (dyskinesia, confusion, visual hallucinations). In this article, the evidence for sub-optical adherence in Parkinson's disease (PD) is reviewed, and factors associated with sub-optimal compliance were examined, with two case vignettes to illustrate clinical consequences of deviation from the prescribed therapy regimen.

Item Type:Articles
Additional Information:Donald Grosset, on behalf of the European PD Therapy Compliance Study Group.
Glasgow Author(s) Enlighten ID:Grosset, Dr Donald
Authors: Grosset, D.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Journal of the Neurological Sciences
ISSN (Online):1878-5883
Published Online:29 September 2009
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