Malek, N. and Grosset, D. G. (2015) Overview of dopamine transporter imaging in Parkinson's disease, dementia with lewy bodies and other dementias. Current Geriatrics Reports, 4(2), pp. 124-130. (doi: 10.1007/s13670-015-0126-9)
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Abstract
123I FP-CIT is a radiotracer that is used in conjunction with single photon emission computed tomography (SPECT) scanning to detect dopaminergic neuron pre-synaptic terminal degeneration, in the striatum (caudate nucleus and putamen) of patients with Parkinson’s disease (PD) and dementia with Lewy bodies (DLB), showing a reduced uptake of this ligand by the dopamine transporters (DaT). This is a licensed diagnostic test in Europe (as DaTSCAN) and in the USA (as DaTscan). Recent work on functional imaging in PD and DLB largely uses the FP-CIT SPECT approach, and this is the focus of our paper, whilst noting that other ligands (e.g. beta-CIT) and imaging techniques such as positron emission tomography (PET) have been used in similar settings.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Grosset, Professor Donald |
Authors: | Malek, N., and Grosset, D. G. |
College/School: | College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience |
Journal Name: | Current Geriatrics Reports |
Publisher: | Springer |
ISSN: | 2196-7865 |
ISSN (Online): | 2196-7865 |
Published Online: | 01 April 2015 |
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