The NF-KB pathway and endocrine therapy resistance in breast cancer

Khongthong, P., Roseweir, A. K. and Edwards, J. (2019) The NF-KB pathway and endocrine therapy resistance in breast cancer. Endocrine-Related Cancer, 26(6), R369-R380. (doi: 10.1530/ERC-19-0087) (PMID:32013374)

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Abstract

Breast cancer is a heterogeneous disease, which over time acquires various adaptive changes leading to more aggressive biological characteristics and development of treatment resistance. Several mechanisms of resistance have been established; however, due to the complexity of oestrogen receptor (ER) signalling and its crosstalk with other signalling networks, various areas still need to be investigated. This article focusses on the role of nuclear factor kappa B (NF-KB) as a key link between inflammation and cancer and addresses its emerging role as a key player in endocrine therapy resistance. Understanding the precise mechanism of NF-KB-driven endocrine therapy resistance provides a possible opportunity for therapeutic intervention.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Roseweir, Dr Antonia and Khongthong, Phungern and Edwards, Professor Joanne
Authors: Khongthong, P., Roseweir, A. K., and Edwards, J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Endocrine-Related Cancer
Publisher:BioScientifica
ISSN:1351-0088
ISSN (Online):1479-6821
Published Online:04 April 2019

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