Age-related clonal haemopoiesis is associated with increased epigenetic age

Robertson, N. A., Hillary, R. F., McCartney, D. L., Terradas-Terradas, M., Higham, J., Sproul, D., Deary, I. J., Kirschner, K. , Marioni, R. E. and Chandra, T. (2019) Age-related clonal haemopoiesis is associated with increased epigenetic age. Current Biology, 29(16), R786-R787. (doi:10.1016/j.cub.2019.07.011) (PMID:31430471)

[img] Text
191231.pdf - Accepted Version
Restricted to Repository staff only until 19 August 2020.

209kB
[img] Text
191231Supp.pdf - Supplemental Material
Restricted to Repository staff only until 19 August 2020.

320kB
[img] Other (spreadsheet)
191231supptable.xlsx - Supplemental Material
Restricted to Repository staff only until 19 August 2020.

20kB

Abstract

Age-related clonal haemopoiesis (ARCH) in healthy individuals was initially observed through an increased skewing in X-chromosome inactivation [1]. More recently, several groups reported that ARCH is driven by somatic mutations [2], with the most prevalent ARCH mutations being in the DNMT3A and TET2 genes, previously described as drivers of myeloid malignancies. ARCH is associated with an increased risk for haematological cancers [2]. ARCH also confers an increased risk for non-haematological diseases, such as cardiovascular disease, atherosclerosis, and chronic ischemic heart failure, for which age is a main risk factor 3, 4. Whether ARCH is linked to accelerated ageing has remained unexplored. The most accurate and commonly used tools to measure age acceleration are epigenetic clocks: they are based on age-related methylation differences at specific CpG sites [5]. Deviations from chronological age towards an increased epigenetic age have been associated with increased risk of earlier mortality and age-related morbidities 5, 6. Here we present evidence of accelerated epigenetic age in individuals with ARCH.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Kirschner, Dr Kristina and Robertson, Mr Neil
Authors: Robertson, N. A., Hillary, R. F., McCartney, D. L., Terradas-Terradas, M., Higham, J., Sproul, D., Deary, I. J., Kirschner, K., Marioni, R. E., and Chandra, T.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Current Biology
Publisher:Elsevier (Cell Press)
ISSN:0960-9822
ISSN (Online):1879-0445
Published Online:19 August 2019
Copyright Holders:Crown Copyright © 2019
First Published:First published in Current Biology 29(16):R786-R787
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

University Staff: Request a correction | Enlighten Editors: Update this record