Epigenetic regulation of biological rhythms: an evolutionary ancient molecular timer

Stevenson, T. J. (2018) Epigenetic regulation of biological rhythms: an evolutionary ancient molecular timer. Trends in Genetics, 34(2), pp. 90-100. (doi: 10.1016/j.tig.2017.11.003) (PMID:29221677)

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Abstract

Biological rhythms are pervasive in nature, yet our understanding of the molecular mechanisms that govern timing is far from complete. The rapidly emerging research focus on epigenetic plasticity has revealed a system that is highly dynamic and reversible. In this Opinion, I propose an epigenetic clock model that outlines how molecular modifications, such as DNA methylation, are integral components for timing endogenous biological rhythms. The hypothesis proposed is that an epigenetic clock serves to maintain the period of molecular rhythms via control over the phase of gene transcription and this timing mechanism resides in all cells, from unicellular to complex organisms. The model also provides a novel framework for the timing of epigenetic modifications during the lifespan and transgenerational inheritance of an organism.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Stevenson, Dr Tyler
Authors: Stevenson, T. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:Trends in Genetics
Publisher:Elsevier
ISSN:0168-9525
ISSN (Online):1362-4555
Published Online:05 December 2017
Copyright Holders:Copyright © 2017 Elsevier
First Published:First published in Trends in Genetics 34(2):90-100
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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