A comparative perspective on extra-retinal photoreception

Perez, J. H., Tolla, E., Dunn, I. C., Meddle, S. L. and Stevenson, T. J. (2019) A comparative perspective on extra-retinal photoreception. Trends in Endocrinology and Metabolism, 30(1), pp. 39-53. (doi: 10.1016/j.tem.2018.10.005) (PMID:30522810)

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Abstract

Ubiquitous in non-mammalian vertebrates, extra-retinal photoreceptors (ERPs) have been linked to an array of physiological, metabolic, behavioral, and morphological changes. However, the mechanisms and functional roles of ERPs remain one of the enduring questions of modern biology. In this review article, we use a comparative framework to identify conserved roles and distributions of ERPs, highlighting knowledge gaps. We conclude that ERP research can be divided into two largely unconnected categories: (i) identification and localization of photoreceptors and (ii) linkage of non-retinal light reception to behavioral and physiological processes, particularly endocrine systems. However, the emergence of novel gene editing and silencing techniques is enabling the unification of ERP research by allowing the bridging of this divide.

Item Type:Articles
Additional Information:This work was funded by a Leverhulme Trust Research Project grant awarded to T.J.S., S.L.M., and I.C.D. S.L.M. and I.C. D. acknowledge funding from the Biotechnology and Biological Sciences Research Council, Institute Strategic Program grant BB/PO13759/1.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Perez, Dr Jonathan and Stevenson, Dr Tyler
Authors: Perez, J. H., Tolla, E., Dunn, I. C., Meddle, S. L., and Stevenson, T. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:Trends in Endocrinology and Metabolism
Publisher:Elsevier
ISSN:1043-2760
ISSN (Online):1879-3061
Published Online:05 December 2019
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Trends in Endocrinology and Metabolism 30(1):39-53
Publisher Policy:Reproduced under a Creative Commons License

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