Altered gut and adipose tissue hormones in overweight and obese individuals: cause or consequence?

Lean, M.E.J. and Malkova, D. (2016) Altered gut and adipose tissue hormones in overweight and obese individuals: cause or consequence? International Journal of Obesity, 40(4), pp. 622-632. (doi: 10.1038/ijo.2015.220) (PMID:26499438) (PMCID:PMC4827002)

190859.pdf - Published Version
Available under License Creative Commons Attribution.



The aim of this article is to review the research into the main peripheral appetite signals altered in human obesity, together with their modifications after body weight loss with diet and exercise and after bariatric surgery, which may be relevant to strategies for obesity treatment. Body weight homeostasis involves the gut–brain axis, a complex and highly coordinated system of peripheral appetite hormones and centrally mediated neuronal regulation. The list of peripheral anorexigenic and orexigenic physiological factors in both animals and humans is intimidating and expanding, but anorexigenic glucagon-like peptide 1 (GLP-1), cholecystokinin (CCK), peptide YY (PYY) and orexigenic ghrelin from the gastrointestinal tract, pancreatic polypeptide (PP) from the pancreas and anorexigenic leptin from adiposites remain the most widely studied hormones. Homeostatic control of food intake occurs in humans, although its relative importance for eating behaviour is uncertain, compared with social and environmental influences. There are perturbations in the gut–brain axis in obese compared with lean individuals, as well as in weight-reduced obese individuals. Fasting and postprandial levels of gut hormones change when obese individuals lose weight, either with surgical or with dietary and/or exercise interventions. Diet-induced weight loss results in long-term changes in appetite gut hormones, postulated to favour increased appetite and weight regain while exercise programmes modify responses in a direction expected to enhance satiety and permit weight loss and/or maintenance. Sustained weight loss achieved by bariatric surgery may in part be mediated via favourable changes to gut hormones. Future work will be necessary to fully elucidate the role of each element of the axis, and whether modifying these signals can reduce the risk of obesity.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Lean, Professor Michael and Malkova, Dr Dalia
Authors: Lean, M.E.J., and Malkova, D.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:International Journal of Obesity
Publisher:Nature Publishing Group
ISSN (Online):1476-5497
Published Online:26 October 2015
Copyright Holders:Copyright © 2016 Macmillan Publishers Limited
First Published:First published in International Journal of Obesity 40(4):622-632
Publisher Policy:Reproduced under a Creative Commons License

University Staff: Request a correction | Enlighten Editors: Update this record