Control of Escherichia coli isocitrate dehydrogenase: an example of protein phosphorylation in a prokaryote

Nimmo, H.G. (1984) Control of Escherichia coli isocitrate dehydrogenase: an example of protein phosphorylation in a prokaryote. Trends in Biochemical Sciences, 9(11), pp. 475-478. (doi: 10.1016/0968-0004(84)90315-3)

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Abstract

In micro-organisms growing on acetate, isocitrate can be metabolized either by the tricarboxylic acid cycle or by the glyoxylate bypass. In Escherichia coli this branch-point is controlled by reversible phosphorylation and inactivation of isocitrate dehydrogenase. Both phosphorylation and dephosphorylation are catalysed by a single bifunctional kinase/phosphatase. The properties of this enzyme suggest that phosphorylation of isocitrate dehydrogenase is controlled by the concentrations of several central metabolites, including isocitrate, the adenine nucleotides and phoenolpyruvate.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Nimmo, Professor Hugh
Authors: Nimmo, H.G.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:Trends in Biochemical Sciences
Publisher:Elsevier Science
ISSN:0968-0004
ISSN (Online):1362-4326

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