Nimmo, H.G. (1984) Control of Escherichia coli isocitrate dehydrogenase: an example of protein phosphorylation in a prokaryote. Trends in Biochemical Sciences, 9(11), pp. 475-478. (doi: 10.1016/0968-0004(84)90315-3)
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Abstract
In micro-organisms growing on acetate, isocitrate can be metabolized either by the tricarboxylic acid cycle or by the glyoxylate bypass. In Escherichia coli this branch-point is controlled by reversible phosphorylation and inactivation of isocitrate dehydrogenase. Both phosphorylation and dephosphorylation are catalysed by a single bifunctional kinase/phosphatase. The properties of this enzyme suggest that phosphorylation of isocitrate dehydrogenase is controlled by the concentrations of several central metabolites, including isocitrate, the adenine nucleotides and phoenolpyruvate.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Nimmo, Professor Hugh |
| Authors: | Nimmo, H.G. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
| Journal Name: | Trends in Biochemical Sciences |
| Publisher: | Elsevier Science |
| ISSN: | 0968-0004 |
| ISSN (Online): | 1362-4326 |
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