Purine and pyrimidine transport in pathogenic protozoa: From biology to therapy

De Koning, H. P. , Bridges, D. J. and Burchmore, R. J. S. (2005) Purine and pyrimidine transport in pathogenic protozoa: From biology to therapy. FEMS Microbiology Reviews, 29(5), pp. 987-1020. (doi:10.1016/j.femsre.2005.03.004)

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Publisher's URL: http://dx.doi.org/10.1016/j.femsre.2005.03.004

Abstract

Purine salvage is an essential function for all obligate parasitic protozoa studied to date and most are also capable of efficient uptake of preformed pyrimidines. Much progress has been made in the identification and characterisation of protozoan purine and pyrimidine transporters. While the genes encoding protozoan or metazoan pyrimidine transporters have yet to be identified, numerous purine transporters have now been cloned. All protozoan purine transporter-encoding genes characterised to date have been of the Equilibrative Nucleoside Transporter family conserved in a great variety of eukaryote organisms. However, these protozoan transporters have been shown to be sufficiently different from mammalian transporters to mediate selective uptake of therapeutic agents. Recent studies are increasingly addressing the structure and substrate recognition mechanisms of these vital transport proteins.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Burchmore, Dr Richard and De Koning, Professor Harry
Authors: De Koning, H. P., Bridges, D. J., and Burchmore, R. J. S.
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:FEMS Microbiology Reviews
Publisher:Wiley
ISSN:0168-6445
ISSN (Online):1574-6976
Published Online:10 April 2006

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