Chitosan-Graphene Oxide based ultra-thin and flexible sensor for diabetic wound monitoring

Kafi, M. A., Paul, A., Vilouras, A. , Hosseini, E. S. and Dahiya, R. S. (2019) Chitosan-Graphene Oxide based ultra-thin and flexible sensor for diabetic wound monitoring. IEEE Sensors Journal, (doi:10.1109/JSEN.2019.2928807) (Early Online Publication)

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Abstract

This work presents a Chitosan - Graphene Oxide (CS-GO) based array of ultra-thin biosensors with gold (Au) based microgap (60μm) electrode. The cross-linked GO is shown to improve the stability of chitosan substrate in aqueous medium and compatibility with microfabrication steps. The sensor patch has been evaluated for label free monitoring by immobilizing the CS-GO surface with human dermal fibroblast (HDF) cells. The cyclic voltammetry (CV) of HDF cell immobilized CS-GO surface show quasi-reversible nature with characteristic cathodic peak at 300mV and anodic peak at +300mV. Both peaks are stable and repeatable up to 50-scan cycle without any potential shift. The device shows steady state peak enhancement (1.923-11.195nA) during the DHF cell growth period (0-96h). The redox peak enhancement correlates with the cell proliferation rates over time, indicating that it could be employed for investigation of cyto-physiological state against any endo and exogenous stimulation. In addition, the developed sensor-patch was used to detect a wide range of glucose from 1μM to 20mM in vitro with a sensitivity of 0.17μA/mM. Considering these, the presented sensor-patch has a great potential for the detection of glucose level, cell-health proliferation rate at the wound site and diabetic wound monitoring applications.

Item Type:Articles
Status:Early Online Publication
Refereed:Yes
Glasgow Author(s) Enlighten ID:Vilouras, Anastasios and Kafi, Md Abdul and Dahiya, Professor Ravinder and Seyed Hosseini, Dr Ensieh and Paul, Dr Ambarish
Authors: Kafi, M. A., Paul, A., Vilouras, A., Hosseini, E. S., and Dahiya, R. S.
College/School:College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering
Journal Name:IEEE Sensors Journal
Publisher:IEEE
ISSN:1530-437X
ISSN (Online):1558-1748
Published Online:15 July 2019
Copyright Holders:Copyright © 2019 IEEE
First Published:First published in IEEE Sensors Journal 2019
Publisher Policy:Reproduced under a Creative Commons license

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
718761BENDRavinder DahiyaEuropean Commission (EC)704807ENG - ENGINEERING ELECTRONICS & NANO ENG
663861Engineering Fellowships for Growth: Printed Tactile SKINRavinder DahiyaEngineering and Physical Sciences Research Council (EPSRC)EP/M002527/1ENG - ENGINEERING ELECTRONICS & NANO ENG
636381EPSRC Centre for Doctoral Training in Sensing and MeasurementAndrew HarveyEngineering and Physical Sciences Research Council (EPSRC)EP/L016753/1S&E P&A - PHYSICS & ASTRONOMY
663861Engineering Fellowships for Growth: Printed Tactile SKINRavinder DahiyaEngineering and Physical Sciences Research Council (EPSRC)EP/M002527/1ENG - ENGINEERING ELECTRONICS & NANO ENG
3017280Engineering Fellowships for Growth: Printed Tactile SKINRavinder DahiyaEngineering and Physical Sciences Research Council (EPSRC)EP/R029644/1ENG - Electronics & Nanoscale Engineering