Effect of prior moderate exercise on postprandial metabolism in men with type 2 diabetes: Heterogeneity of responses

Gill, J.M. , Al-Mamari, A., Ferrell, W.R., Cleland, S.J., Perry, C.G., Sattar, N. , Packard, C.J. , Caslake, M.J. and Petrie, J.R. (2007) Effect of prior moderate exercise on postprandial metabolism in men with type 2 diabetes: Heterogeneity of responses. Atherosclerosis, 194(1), pp. 134-143. (doi:10.1016/j.atherosclerosis.2006.10.007)

Gill, J.M. , Al-Mamari, A., Ferrell, W.R., Cleland, S.J., Perry, C.G., Sattar, N. , Packard, C.J. , Caslake, M.J. and Petrie, J.R. (2007) Effect of prior moderate exercise on postprandial metabolism in men with type 2 diabetes: Heterogeneity of responses. Atherosclerosis, 194(1), pp. 134-143. (doi:10.1016/j.atherosclerosis.2006.10.007)

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Abstract

Prior moderate exercise has been shown consistently to reduce postprandial triglyceride (TG) concentrations in non-diabetic adults, but its effects in men with type 2 diabetes are not known. This study aimed to determine the effect of moderate exercise on postprandial metabolism in men with type 2 diabetes. Ten middle-aged men with type 2 diabetes underwent two oral fat tolerance tests (blood taken fasting and for 8 h after a meal containing 80 g fat, 70 g carbohydrate) in random order. On the afternoon before one test, participants performed a 90-min treadmill walk (Exercise); no exercise was performed before the Control test. Exercise significantly reduced fasting glucose (Control: 9.08 ± 0.75 mmol l−1, Exercise: 8.40 ± 0.72 mmol l−1, p = 0.033) and insulin (Control: 8.01 ± 0.98 μU ml−1, Exercise: 6.81 ± 0.93 μU ml−1, p = 0.046) and increased fasting 3-hydroxybutyrate (Control: 87.1 ± 19.2 μmol l−1, Exercise: 134.3 ± 28.4 μmol l−1, p = 0.011); reduced postprandial insulin by 11.0% (p = 0.04) and increased postprandial 3-hydroxybutrate by 31.8% (p = 0.03); but did not significantly change fasting or postprandial triglyceride or NEFA concentrations. However, the exercise-induced change in postprandial triglyceride concentration ranged from −32.3 to +28.3% and the exercise-induced change in fasting 3-hydroxybutyrate concentration (a marker of hepatic fatty acid oxidation) was highly correlated with the exercise-induced changes in fasting and postprandial triglyceride (r = 0.68, p = 0.03 for both). Thus, inter-individual variation in propensity to increase hepatic fatty acid oxidation following exercise may account for the considerable heterogeneity in triglyceride responses to moderate exercise observed in men with type 2 diabetes.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Gill, Professor Jason and Perry, Dr Colin and Caslake, Professor Muriel and Petrie, Professor John and Cleland, Dr Stephen and Ferrell, Professor William and Packard, Professor Chris and Sattar, Professor Naveed
Authors: Gill, J.M., Al-Mamari, A., Ferrell, W.R., Cleland, S.J., Perry, C.G., Sattar, N., Packard, C.J., Caslake, M.J., and Petrie, J.R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Atherosclerosis
Publisher:Elsevier Ireland Ltd
ISSN:0021-9150
ISSN (Online):1879-1484
Published Online:07 November 2006

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