Silva-Santos, B., Mensurado, S. and Coffelt, S. B. (2019) γδ T cells: pleiotropic immune effectors with therapeutic potential in cancer. Nature Reviews Cancer, 19(7), pp. 392-404. (doi: 10.1038/s41568-019-0153-5) (PMID:31209264)
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Abstract
The potential of cancer immunotherapy relies on the mobilization of immune cells capable of producing antitumour cytokines and effectively killing tumour cells. These are major attributes of γδ T cells, a lymphoid lineage that is often underestimated despite its major role in tumour immune surveillance, which has been established in a variety of preclinical cancer models. This situation notwithstanding, in particular instances the tumour microenvironment seemingly mobilizes γδ T cells with immunosuppressive or tumour-promoting functions, thus emphasizing the importance of regulating γδ T cell responses in order to realize their translation into effective cancer immunotherapies. In this Review we outline both seminal work and recent advances in our understanding of how γδ T cells participate in tumour immunity and how their functions are regulated in experimental models of cancer. We also discuss the current strategies aimed at maximizing the therapeutic potential of human γδ T cells, on the eve of their exploration in cancer clinical trials that may position them as key players in cancer immunotherapy.
| Item Type: | Articles |
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| Additional Information: | We acknowledge funding from the European Research Council (CoG_646701 to B.S.-S.), Cancer Research UK Glasgow Centre (A25142 to S.B.C.), Breast Cancer Now (2018JulPR1101 to S.B.C.), Wellcome Trust (208990/Z/17/Z to S.B.C.), Tenovus Scotland (Project S17-17 to S.B.C.) and Fundação para a Ciência e a Tecnologia / Ministério da Ciência, Tecnologia e Ensino Superior through Fundos do Orçamento de Estado (refs. UID/BIM/50005/2019 and PD/BD/114099/2015). |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Coffelt, Professor Seth |
| Authors: | Silva-Santos, B., Mensurado, S., and Coffelt, S. B. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Research Centre: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Immunobiology |
| Journal Name: | Nature Reviews Cancer |
| Publisher: | Nature Research |
| ISSN: | 1474-175X |
| ISSN (Online): | 1474-1768 |
| Published Online: | 17 June 2019 |
| Copyright Holders: | Copyright © 2019 Springer Nature |
| First Published: | First published in Nature Reviews Cancer 19(7):392-404 |
| Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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