γδ T cells: pleiotropic immune effectors with therapeutic potential in cancer

Silva-Santos, B., Mensurado, S. and Coffelt, S. B. (2019) γδ T cells: pleiotropic immune effectors with therapeutic potential in cancer. Nature Reviews Cancer, 19(7), pp. 392-404. (doi:10.1038/s41568-019-0153-5) (PMID:31209264)

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Abstract

The potential of cancer immunotherapy relies on the mobilization of immune cells capable of producing antitumour cytokines and effectively killing tumour cells. These are major attributes of γδ T cells, a lymphoid lineage that is often underestimated despite its major role in tumour immune surveillance, which has been established in a variety of preclinical cancer models. This situation notwithstanding, in particular instances the tumour microenvironment seemingly mobilizes γδ T cells with immunosuppressive or tumour-promoting functions, thus emphasizing the importance of regulating γδ T cell responses in order to realize their translation into effective cancer immunotherapies. In this Review we outline both seminal work and recent advances in our understanding of how γδ T cells participate in tumour immunity and how their functions are regulated in experimental models of cancer. We also discuss the current strategies aimed at maximizing the therapeutic potential of human γδ T cells, on the eve of their exploration in cancer clinical trials that may position them as key players in cancer immunotherapy.

Item Type:Articles
Additional Information:We acknowledge funding from the European Research Council (CoG_646701 to B.S.-S.), Cancer Research UK Glasgow Centre (A25142 to S.B.C.), Breast Cancer Now (2018JulPR1101 to S.B.C.), Wellcome Trust (208990/Z/17/Z to S.B.C.), Tenovus Scotland (Project S17-17 to S.B.C.) and Fundação para a Ciência e a Tecnologia / Ministério da Ciência, Tecnologia e Ensino Superior through Fundos do Orçamento de Estado (refs. UID/BIM/50005/2019 and PD/BD/114099/2015).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Coffelt, Dr Seth
Authors: Silva-Santos, B., Mensurado, S., and Coffelt, S. B.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Nature Reviews Cancer
Publisher:Nature Research
ISSN:1474-175X
ISSN (Online):1474-1768
Published Online:17 June 2019
Copyright Holders:Copyright © 2019 Springer Nature
First Published:First published in Nature Reviews Cancer 19(7):392-404
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
742771CRUK Centre RenewalOwen SansomCancer Research UK (CRUK)C7932/A25142ICS - BEATSON INSTITUTE FOR CANCER RES.
742772CRUK Centre RenewalOwen SansomCancer Research UK (CRUK)C7932/A25142ICS - BEATSON INSTITUTE FOR CANCER RES.
3034570Regulation of IL-17-producing T cells in breast cancer metastasisSeth CoffeltBreast Cancer Now (BRCANNOW)2018JulPR1101CS - Beatson Institute for Cancer Research
3010100understanding gamma delta T cell function in colorectal cancer metastasisSeth CoffeltWellcome Trust (WELLCOTR)208990/Z/17/ZCS - Beatson Institute for Cancer Research
3018370Insights into the behaviour of anti-metastatic T cellsSeth CoffeltTenovus Scotland (TENOVUS)S17-17CS - Beatson Institute for Cancer Research