Development of near-infrared region luminescent N-acetyl-L-cysteine-coated Ag2S quantum dots with differential therapeutic effect

Turhan Buz, P., Demir Duman, F. , Erkisa, M., Demirci, G., Ari, F., Ulukaya, E. and Yagci Acar, H. (2019) Development of near-infrared region luminescent N-acetyl-L-cysteine-coated Ag2S quantum dots with differential therapeutic effect. Nanomedicine, 14, 8. (doi: 10.2217/nnm-2018-0214)

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Abstract

Aim: N-acetyl-L-cysteine (NAC) is a free radical scavenger. We developed NAC-coated Ag2S (NAC-Ag2S) quantum dot (QD) as an optical imaging and therapeutic agent. Materials & methods: QDs were synthesized in water. Their optical imaging potential and toxicity were studied in vitro. Results: NAC-Ag2S QDs have strong emission, that is tunable between 748 and 840 nm, and are stable in biologically relevant media. QDs showed significant differences both in cell internalization and toxicity in vitro. QDs were quite toxic to breast and cervical cancer cells but not to lung derived cells despite the higher uptake. NAC-Ag2S reduces reactive oxygen species (ROS) but causes cell death via DNA damage and apoptosis. Conclusion: NAC-Ag2S QDs are stable and strong signal-generating theranostic agents offering selective therapeutic effects.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Demir Duman, Dr Fatma
Authors: Turhan Buz, P., Demir Duman, F., Erkisa, M., Demirci, G., Ari, F., Ulukaya, E., and Yagci Acar, H.
Subjects:Q Science > QD Chemistry
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Nanomedicine
Publisher:Future Medicine
ISSN:1743-5889
ISSN (Online):1748-6963
Copyright Holders:Copyright © 2019 Future Science Group
First Published:First published in Nanomedicine 14:8
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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