IL-33 is a chemoattractant for human Th2 cells

Komai-Koma, M., Li, Y., Liew, F. Y., McInnes, I. B. , McKenzie, A. N. J. and Xu, D. (2007) IL-33 is a chemoattractant for human Th2 cells. European Journal of Immunology, 37(10), pp. 2779-2786. (doi:10.1002/eji.200737547) (PMID:17853410)

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Abstract

IL-33 is a novel cytokine of the IL-1 family and mediates its biological effect via the receptor ST2, which is selectively expressed on Th2 cells but not Th1 cells. IL-33 drives production of Th2-associated cytokines including IL-5 and IL-13 and thereby promotes defense and pathology in mucosal organs. Cell locomotion is crucial to the induction of an effective immune response. We report here the chemoattraction of Th2 cells by IL-33. Recombinant IL-33 increased the proportion of human Th2 cells, but not Th1 cells, in polarized morphology in vitro and stimulated their subsequent invasion into collagen gels in an IL-33 concentration-dependent manner. Injection of recombinant IL-33 into the footpad of ST2–/– mice which had been adoptively transferred with polarized Th2 cells, led to local accumulation of the transferred Th2 cells. These data therefore demonstrate that IL-33 is a selective Th2 chemoattractant associated with the pro-inflammatory property of this novel cytokine.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McInnes, Professor Iain and Liew, Professor Foo and Xu, Dr Damo and Komai-Koma, Dr Mousa
Authors: Komai-Koma, M., Li, Y., Liew, F. Y., McInnes, I. B., McKenzie, A. N. J., and Xu, D.
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:European Journal of Immunology
Journal Abbr.:Eur. J. Immunol.
Publisher:Wiley-Blackwell Publishing
ISSN:0014-2980
ISSN (Online):1521-4141
Published Online:12 September 2007

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
380241Toll-like receptors on T cellsFoo LiewMedical Research Council (MRC)G9818261Infection Immunity and Inflammation Medicine