Patient maintained sedation for colonoscopy using a target controlled infusion of propofol

Campbell, L., Imrie, G., Doherty, P., Porteous, C., Millar, K., Kenny, G.N.C. and Fletcher, G. (2004) Patient maintained sedation for colonoscopy using a target controlled infusion of propofol. Division of Developmental Medicine, 59(2), pp. 127-132. (doi:10.1111/j.1365-2044.2004.03580.x)

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Abstract

In this study, we evaluated safety and recovery using a patient maintained, target controlled infusion of propofol for sedation in 20 patients undergoing colonoscopy. Using a handset with a two-minute lockout interval, patients could make 0.2 µg.ml−1 increments to an initial target plasma concentration of 1 µg.ml−1 up to a maximum 4.5 µg.ml−1. Four patients became oversedated but required no airway or circulatory interventions. Subjects had a significant reduction in mean (SD) heart rate: 78.7 (15) vs. 69.8 (13.5) (p < 0.001) and in systolic blood pressure 121.1 (13.2) mmHg vs. 96.5 (8.6) mmHg (p < 0.001). Choice reaction time testing 15 min after colonoscopy showed a significant median (IQR [range]) rise of 162 (− 16, 383.3 [-199–859]) ms (p < 0.05). Six patients had faster reaction times postcolonoscopy. All patients denied unpleasant recall and were satisfied with the system. Although oversedation was a problem in this model, we conclude that patient maintained propofol sedation could be possible for colonoscopy.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Kenny, Prof Gavin and Millar, Professor Keith
Authors: Campbell, L., Imrie, G., Doherty, P., Porteous, C., Millar, K., Kenny, G.N.C., and Fletcher, G.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Clinical Specialities
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Mental Health and Wellbeing
Journal Name:Division of Developmental Medicine
Publisher:1365-2044
ISSN:Anaesthesia
ISSN (Online):0003-2409
Published Online:16 January 2004

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