Campbell, L., Imrie, G., Doherty, P., Porteous, C., Millar, K., Kenny, G.N.C. and Fletcher, G. (2004) Patient maintained sedation for colonoscopy using a target controlled infusion of propofol. Division of Developmental Medicine, 59(2), pp. 127-132. (doi: 10.1111/j.1365-2044.2004.03580.x)
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Abstract
In this study, we evaluated safety and recovery using a patient maintained, target controlled infusion of propofol for sedation in 20 patients undergoing colonoscopy. Using a handset with a two-minute lockout interval, patients could make 0.2 µg.ml−1 increments to an initial target plasma concentration of 1 µg.ml−1 up to a maximum 4.5 µg.ml−1. Four patients became oversedated but required no airway or circulatory interventions. Subjects had a significant reduction in mean (SD) heart rate: 78.7 (15) vs. 69.8 (13.5) (p < 0.001) and in systolic blood pressure 121.1 (13.2) mmHg vs. 96.5 (8.6) mmHg (p < 0.001). Choice reaction time testing 15 min after colonoscopy showed a significant median (IQR [range]) rise of 162 (− 16, 383.3 [-199–859]) ms (p < 0.05). Six patients had faster reaction times postcolonoscopy. All patients denied unpleasant recall and were satisfied with the system. Although oversedation was a problem in this model, we conclude that patient maintained propofol sedation could be possible for colonoscopy.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Millar, Professor Keith and Kenny, Prof Gavin |
| Authors: | Campbell, L., Imrie, G., Doherty, P., Porteous, C., Millar, K., Kenny, G.N.C., and Fletcher, G. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Clinical Specialities College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Mental Health and Wellbeing |
| Journal Name: | Division of Developmental Medicine |
| Publisher: | 1365-2044 |
| ISSN: | Anaesthesia |
| ISSN (Online): | 0003-2409 |
| Published Online: | 16 January 2004 |
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