Low temperature aqueous living/controlled (RAFT) polymerization of carboxybetaine methacrylamide up to high molecular weights

Rodriguez‐Emmenegger, C., Schmidt, B. V.K.J. , Sedlakova, Z., Šubr, V., Bologna Alles, A., Brynda, E. and Barner‐Kowollik, C. (2011) Low temperature aqueous living/controlled (RAFT) polymerization of carboxybetaine methacrylamide up to high molecular weights. Macromolecular Rapid Communications, 32(13), pp. 958-965. (doi:10.1002/marc.201100176) (PMID:21648007)

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Abstract

Among the class of zwitterionic polymers poly(carboxybetaine)s (poly(CB)s) are unique, emerging as the only ultra‐low fouling materials known allowing the preparation of biosensors, fouling resistant nanoparticles, and non‐adhesive surfaces for bacteria. Poly(carboxybetaine methacrylate) and poly(carboxybetaine acrylamide) have been prepared via atom transfer radical polymerization (ATRP), however a polymerization with living characteristics has not been achieved yet. Herein, the first successful living/controlled reversible addition fragmentation transfer (RAFT) polymerization of (3‐methacryloylamino‐propyl)‐(2‐carboxy‐ethyl)‐dimethyl‐ammonium (carboxybetaine methacrylamide) (CBMAA‐3) in acetate buffer (pH 5.2) at 70 and 37 °C is reported. The polymerization afforded very high molecular weight polymers (determined by absolute size exclusion chromatography, close to 250 000 g · mol−1 in less than 6 h) with low PDI (<1.3) at 70 °C. The polymerization was additionally carried out at 37 °C allowing to achieve yet lower PDIs (1.06 ≤ PDI ≤ 1.15) even at 90% conversion, demonstrating the suitability of the polymerization conditions for bioconjugate grafting. The living character of the polymerization is additionally evidenced by chain extending poly(CBMAA‐3) at 70 and 37 °C. Block copolymerization from biologically relevant poly[N‐(2‐hydroxypropyl)methacrylamide] macroCTAs was additionally performed.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Schmidt, Dr Bernhard
Authors: Rodriguez‐Emmenegger, C., Schmidt, B. V.K.J., Sedlakova, Z., Šubr, V., Bologna Alles, A., Brynda, E., and Barner‐Kowollik, C.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Macromolecular Rapid Communications
Publisher:Wiley
ISSN:1022-1336
ISSN (Online):1521-3927
Published Online:03 June 2011

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