Candida auris exhibits resilient biofilm characteristics in vitro: implications for environmental persistence

Short, B., Brown, J. , Delaney, C., Sherry, L., Williams, C., Ramage, G. and Kean, R. (2019) Candida auris exhibits resilient biofilm characteristics in vitro: implications for environmental persistence. Journal of Hospital Infection, 31226270. (doi:10.1016/j.jhin.2019.06.006) (Early Online Publication)

Short, B., Brown, J. , Delaney, C., Sherry, L., Williams, C., Ramage, G. and Kean, R. (2019) Candida auris exhibits resilient biofilm characteristics in vitro: implications for environmental persistence. Journal of Hospital Infection, 31226270. (doi:10.1016/j.jhin.2019.06.006) (Early Online Publication)

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Abstract

Surfaces within healthcare play a key role in the transmission of drug-resistant pathogens. Candida auris is an emerging multi-drug resistant yeast which has the ability to survive for prolonged periods on environmental surfaces. Here we show that the ability to form cellular aggregates increases survival after 14 days, which coincides with the upregulation of biofilm-associated genes. Additionally, the aggregating strain demonstrated tolerance to clinical concentrations of sodium hypochlorite and remain viable 14 days’ post treatment. The ability of C. auris to adhere and persist on environmental surfaces emphasises our need to better understand the biology of this fungal pathogen.

Item Type:Articles
Additional Information:This study has been funded by a research grant in 2017 by the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) to L.S.
Status:Early Online Publication
Refereed:Yes
Glasgow Author(s) Enlighten ID:Kean, Mr Ryan and Williams, Dr Craig and Sherry, Dr Leighann and Brown, Mr Jason and Ramage, Professor Gordon and Delaney, Christopher
Authors: Short, B., Brown, J., Delaney, C., Sherry, L., Williams, C., Ramage, G., and Kean, R.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
Journal Name:Journal of Hospital Infection
Publisher:Elsevier
ISSN:0195-6701
ISSN (Online):1532-2939
Published Online:18 June 2019

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