Braconi, C. , Roessler, S., Kruk, B., Lammert, F., Krawczyk, M. and Andersen, J. B. (2019) Molecular perturbations in cholangiocarcinoma: is it time for precision medicine? Liver International, 39(S1), pp. 32-42. (doi: 10.1111/liv.14085) (PMID:30829432)
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Abstract
The complexity of cholangiocarcinoma (CCA) cellularity and the molecular perturbation mechanisms that underlie the diversity of growth patterns of this malignancy remain a clinical concern. Tumours of the biliary system display significant intrinsic chemoresistance, caused by significant stromal involvement and genome–wide tumour heterogeneity, hampering disease remission and palliation as well as promoting the metastatic behaviour. It is crucial to advance our present understanding of the risk and molecular pathogenesis of CCA. This will facilitate the delineation of patient subsets based on molecular perturbations and adjust for precision therapies.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Braconi, Professor Chiara |
| Authors: | Braconi, C., Roessler, S., Kruk, B., Lammert, F., Krawczyk, M., and Andersen, J. B. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Liver International |
| Publisher: | Wiley |
| ISSN: | 1478-3223 |
| ISSN (Online): | 1478-3231 |
| Published Online: | 04 March 2019 |
| Copyright Holders: | Copyright © 2019 John Wiley & Sons |
| First Published: | First published in Liver International 39(S1):32-42 |
| Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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