Chaudhuri, R., Livingston, E., McMahon, A. D., Lafferty, J., Fraser, I., Spears, M., McSharry, C. P. and Thomson, N. C. (2006) Effects of smoking cessation on lung function and airway inflammation in smokers with asthma. American Journal of Respiratory and Critical Care Medicine, 174(2), pp. 127-133. (doi: 10.1164/rccm.200510-1589OC)
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Publisher's URL: http://dx.doi.org/10.1164/rccm.200510-1589OC
Abstract
<b>Rationale:</b> Active smoking in asthma is associated with worsening of symptoms, accelerated decline in lung function, and impaired response to corticosteroids.<p></p> <b>Objectives:</b> To examine the short-term effects of smoking cessation on lung function, airway inflammation, and corticosteroid responsiveness in smokers with asthma.<p></p> <b>Methods and Measurements:</b> Smokers with asthma were given the option to quit or continue smoking. Both groups underwent spirometry and induced sputum at baseline and at 1, 3, and 6 wk. Cutaneous vasoconstrictor response to topical beclometasone, airway response to oral prednisolone, and sensitivity of peripheral blood lymphocytes to corticosteroids were measured before smoking cessation and at 6 wk.<p></p> <b>Main Results:</b> Of 32 subjects recruited, 11 opted to continue smoking (smoking control group). Of 21 subjects who opted for smoking cessation, 10 quit smoking for 6 wk (quit group). In the comparison of quitters with smokers at 6 wk, the mean (confidence interval [CI]) difference in FEV<sub>1</sub> was 407 ml (21, 793), p = 0.040, and the proportion of sputum neutrophils was reduced by 29 (51, 8), p = 0.039. Total cutaneous vasoconstrictor response score to topical beclometasone improved after smoking cessation with a mean (CI) difference of 3.56 (0.84, 6.28), p = 0.042, between quitters and smokers. There was no change in airway corticosteroid responses after smoking cessation.<p></p> <b>Conclusions:</b> By 6 wk after smoking cessation, subjects who quit smoking had achieved considerable improvement in lung function and a fall in sputum neutrophil count compared with subjects who continued to smoke. These findings highlight the importance of smoking cessation in asthma.<p></p>
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | McMahon, Dr Alex and Spears, Dr Mark and Thomson, Professor Neil and Chaudhuri, Dr Rekha and Lafferty, Mrs Jane and McSharry, Dr Charles |
Authors: | Chaudhuri, R., Livingston, E., McMahon, A. D., Lafferty, J., Fraser, I., Spears, M., McSharry, C. P., and Thomson, N. C. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School |
Journal Name: | American Journal of Respiratory and Critical Care Medicine |
Publisher: | American Thoracic Society |
ISSN: | 1073-449X |
ISSN (Online): | 1535-4970 |
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