Helicobacter pylori colonization in infants in a Periurban Community in Karachi, Pakistan

Nizami, S.Q., Bhutta, Z.A., Weaver, L. and Preston, T. (2005) Helicobacter pylori colonization in infants in a Periurban Community in Karachi, Pakistan. Journal of Pediatric Gastroenterology and Nutrition, 41(2), pp. 191-194.

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Abstract

<b>BACKGROUND:</b> The prevalence and incidence of Helicobacter pylori in children in Pakistan is not known.<p></p> <b>OBJECTIVES:</b> To measure the prevalence and age of acquisition of Helicobacter pylori infection/colonization in infants in a peri-urban community in Karachi, Pakistan.<p></p> <b>SETTING:</b> Field based epidemiologic study in a peri-urban community in Karachi, Pakistan.<p></p> <b>METHODS:</b> Infants aged 1 to 3 months were recruited from a birth cohort from the community. C-urea breath test (C-UBT) was performed on recruitment, and the test was repeated at 2, 3, 6, and 9 months of age.<p></p> <b>RESULTS:</b> One hundred forty-eight infants were recruited and had C-UBT on 319 occasions over a period of 2 years. Two hundred thirty-one=(72%) tests were positive: 80% (49/61) infants at 1 month of age, 79% (33/42) at 2 month of age, 76% (92/121) at 3 month of age, 58% (37/64) at 6 months of age, and 67% (20/30) at 9 months of age.<p></p> <b>CONCLUSIONS:</b> The study reveals an early colonization/infection of infants and a high prevalence of Helicobacter pylori in a peri-urban community in Karachi, Pakistan.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Preston, Professor Thomas
Authors: Nizami, S.Q., Bhutta, Z.A., Weaver, L., and Preston, T.
College/School:College of Science and Engineering > Scottish Universities Environmental Research Centre
Journal Name:Journal of Pediatric Gastroenterology and Nutrition
ISSN:0277-2116
ISSN (Online):1536-4801
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