Statins in the prevention and treatment of heart failure: a review of the evidence

Lee, M. M.Y. , Sattar, N. , McMurray, J. J.V. and Packard, C. J. (2019) Statins in the prevention and treatment of heart failure: a review of the evidence. Current Atherosclerosis Reports, 21(10), 41. (doi:10.1007/s11883-019-0800-z)

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Abstract

Purpose of Review: We summarize the best evidence for statins in the prevention and treatment of heart failure. Recent Findings: In patients with cardiovascular risk factors or established atherosclerotic cardiovascular disease (but without heart failure), statins reduce the risk of incident heart failure—mainly by preventing myocardial infarction although an additional benefit from reducing myocardial ischemia cannot be excluded. However, in patients with established heart failure, statins do not reduce the risk of cardiovascular death, which is mainly caused by pump failure and ventricular arrhythmias. Retrospective analyses, however, suggest that statins may reduce the rate of heart failure hospitalization and atherosclerotic events (which are proportionately much less common in these patients than heart failure hospitalization or death). Summary: Statin therapy should probably be continued in patients with coronary artery disease developing heart failure, although the weak evidence and small benefit may not justify the use of this treatment in very elderly patients with a short life expectancy and in which polypharmacy is a problem.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Lee, Matthew and McMurray, Professor John and Packard, Professor Chris and Sattar, Professor Naveed
Authors: Lee, M. M.Y., Sattar, N., McMurray, J. J.V., and Packard, C. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Current Atherosclerosis Reports
Publisher:Springer
ISSN:1523-3804
ISSN (Online):1534-6242
Published Online:27 July 2019
Copyright Holders:Copyright © 2019 The Authors
First Published:First published in Current Atherosclerosis Reports 21(10): 41
Publisher Policy:Reproduced under a Creative Commons License

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