Calibration of novel protein biomarkers for veterinary clinical pathology: a call for international action

Eckersall, P. D. (2019) Calibration of novel protein biomarkers for veterinary clinical pathology: a call for international action. Frontiers in Veterinary Science, 6, 210. (doi: 10.3389/fvets.2019.00210) (PMID:31312640) (PMCID:PMC6614203)

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Research into the identification and use of protein biomarkers for use in veterinary clinical pathology has produced numerous potential analytes that could become common tests in the future. One problem that has to be overcome in the general acceptance of a novel biomarker is that differing standards for calibration may be developed by individual laboratories or the diagnostic companies that will provide kits for widespread use. This has been apparent in the development of acute phase protein biomarkers such as canine C-reactive protein. In order to overcome this problem an international initiative is required to ensure that assays developed in separate laboratories would have a consistent calibration protocol so that results produced are equivalent. International reference preparations for serum protein analysis for each relevant species should be established for use as primary standard in the calibration of biomarkers for veterinary diagnosis.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Eckersall, Professor David
Authors: Eckersall, P. D.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:Frontiers in Veterinary Science
Publisher:Frontiers Media
ISSN (Online):2297-1769
Copyright Holders:Copyright © 2019 Eckersall
First Published:First published in Frontiers in Veterinary Science 6:210
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
683931Acute phase protein as biomarkers of disease in livestock and aquaculturePeter EckersallBiotechnology and Biological Sciences Research Council (BBSRC)BB/M022021/1RI BIODIVERSITY ANIMAL HEALTH & COMPMED