Chemokine scavenging by D6: a movable feast?

Graham, G. J. and McKimmie, C. S. (2006) Chemokine scavenging by D6: a movable feast? Trends in Immunology, 27, pp. 381-386. (doi: 10.1016/

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The atypical chemokine receptor, D6, is efficient at sequestering and scavenging inflammatory CC chemokines. The absence of D6 blocks the successful resolution of immune responses in models of inflammation, suggesting that CC-chemokine scavenging by D6 is an important component of the resolution phase of in vivo inflammatory responses. Most studies have suggested that lymphatic endothelial cells are the main vehicles for D6 function in vivo. Here, we propose that leukocytes, which also express D6, could be more-effective vehicles for D6 scavenging function. Thus, leukocytes might be the primary cell type that removes inflammatory chemokines from inflamed tissues. We also propose that lymphatic endothelial cell-expressed D6 might have a distinct but complementary role in restricting inflammatory leukocyte access to the lymphatic vasculature.

Item Type:Articles
Glasgow Author(s) Enlighten ID:McKimmie, Dr Clive and Graham, Professor Gerard
Authors: Graham, G. J., and McKimmie, C. S.
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Trends in Immunology
ISSN (Online):1471-4981
Published Online:30 June 2006

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