The role of microRNAs in human liver cancers

Braconi, C. , Henry, J. C., Kogure, T., Schmnittgen, T. and Patel, T. (2011) The role of microRNAs in human liver cancers. Seminars in Oncology, 38(6), pp. 752-763. (doi: 10.1053/j.seminoncol.2011.08.001) (PMID:22082761) (PMCID:PMC3928803)

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Abstract

Hepatocellular carcinoma (HCC) is a primary malignancy of the liver of global importance. Recent studies of the expression and role of microRNA (miRNA) in HCC are providing new insights into disease pathogenesis. In addition, therapeutic efforts targeting specific miRNAs are being evaluated in animal models of HCC. The potential of miRNAs as biomarkers of disease or prognostic markers is being explored. Herein, we review studies of miRNA expression in human HCC, and discuss recent advances in knowledge about the involvement and role of selected miRNAs in disease pathogenesis, as biomarkers, or as therapeutic targets for HCC.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Braconi, Dr Chiara
Authors: Braconi, C., Henry, J. C., Kogure, T., Schmnittgen, T., and Patel, T.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Seminars in Oncology
Publisher:Elsevier
ISSN:0093-7754
ISSN (Online):1532-8708
Published Online:12 November 2011

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