Impact of stroke co-morbidities on cortical collateral flow following ischaemic stroke

Biose, I. J., Dewar, D. , Macrae, I. M. and McCabe, C. (2019) Impact of stroke co-morbidities on cortical collateral flow following ischaemic stroke. Journal of Cerebral Blood Flow and Metabolism, (doi:10.1177/0271678X19858532) (PMID:31234703) (Early Online Publication)

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Acute hyperglycaemia and chronic hypertension worsen stroke outcome but their impact on collateral perfusion, a determinant of penumbral life span, is poorly understood. Laser-speckle contrast imaging (LSCI) was used to determine the influence of these stroke comorbidities on cortical perfusion after permanent middle cerebral artery occlusion (pMCAO) in spontaneously hypertensive stroke prone rats (SHRSP) and normotensive Wistar rats. Four independent studies were conducted. In animals without pMCAO, cortical perfusion remained stable over 180 min. Following pMCAO, cortical perfusion was markedly reduced at 30 min then gradually increased, via cortical collaterals, over the subsequent 3.5 h. In the contralateral non-ischaemic hemisphere, perfusion did not change over time. Acute hyperglycaemia (in normotensive Wistar) and chronic hypertension (SHRSP) attenuated the restoration of cortical perfusion after pMCAO. Inhaled nitric oxide did not influence cortical perfusion in SHRSP following pMCAO. Thus, hyperglycaemia at the time of arterial occlusion or pre-existing hypertension impaired the dynamic recruitment of cortical collaterals after pMCAO. The impairment of collateral recruitment may contribute to the detrimental effects these comorbidities have on stroke outcome.

Item Type:Articles
Additional Information:This study was funded by Tertiary Education Trust Fund and the University of Glasgow.
Status:Early Online Publication
Glasgow Author(s) Enlighten ID:Macrae, Professor I Mhairi and Biose, Ifechukwude Joachim and Dewar, Dr Deborah and McCabe, Dr Chris
Authors: Biose, I. J., Dewar, D., Macrae, I. M., and McCabe, C.
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Journal of Cerebral Blood Flow and Metabolism
ISSN (Online):1559-7016
Published Online:24 June 2019
Copyright Holders:Copyright © 2019 The Authors
First Published:First published in Journal of Cerebral Blood Flow and Metabolism 2019
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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