Successful haemopoietic stem cell transplantation does not correct mannan-binding lectin deficiency

Kilpatrick, D., Stewart, K., Allan, E., McLintock, L., Holyoake, T. and Turner, M. (2005) Successful haemopoietic stem cell transplantation does not correct mannan-binding lectin deficiency. Bone Marrow Transplantation, 35(2), pp. 179-181. (doi: 10.1038/sj.bmt.1704746)

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Abstract

It has been reported that in allogeneic stem cell transplantation, the mannan-binding lectin (MBL) status of the donor has prognostic value for the recipient. Two MBL-deficient patients, with coexisting haematological malignancy, were identified who were treated with bone marrow from donors with normal MBL concentrations. Although both patients engrafted successfully and remain in complete remission, neither seroconverted to the MBL sufficiency status of his donor over a follow-up period exceeding 2 years. This does not support the concept of MBL replacement by stem cell therapy, and does not provide an explanation for high MBL concentrations in stem cell donors protecting recipients from post transplant infections.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Holyoake, Professor Tessa
Authors: Kilpatrick, D., Stewart, K., Allan, E., McLintock, L., Holyoake, T., and Turner, M.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:Bone Marrow Transplantation
ISSN:0268-3369

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