Effects of short-term detraining on postprandial metabolism, endothelial function, and inflammation in endurance-trained men: Dissociation between changes in triglyceride metabolism and endothelial function

Gill, J.M.R. , Caslake, M.J., McAllister, C., Tsofliou, F., Ferrell, W.R., Packard, C.J. and Malkova, D. (2003) Effects of short-term detraining on postprandial metabolism, endothelial function, and inflammation in endurance-trained men: Dissociation between changes in triglyceride metabolism and endothelial function. Journal of Clinical Endocrinology and Metabolism, 88(9), pp. 4328-4335. (doi:10.1210/jc.2003-030226)

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Abstract

Endurance-trained athletes experience a low level of postprandial lipaemia, but this rapidly increases with detraining. We sought to determine whether detraining-induced changes to postprandial metabolism influenced endothelial function and inflammation. Eight endurance-trained men each undertook two oral fat tolerance tests [blood taken fasted and for 6 h following a high-fat test meal (80 g fat, 80 g carbohydrate)]: one during a period of their normal training (trained) and one after 1 wk of no exercise (detrained). Endothelial function in the cutaneous microcirculation was assessed using laser Doppler imaging with iontophoresis in the fasted state and 4 h postprandially during each test. Fasting plasma triglyceride (TG) concentrations increased by 35% with detraining (P = 0.002), as did postprandial plasma (by 53%, P = 0.002), chylomicron (by 68%, P = 0.02) and very low-density lipoprotein (by 51%, P = 0.005) TG concentrations. Endothelial function decreased postprandially in both the trained (by 17%, P = 0.03) and detrained (by 22%, P = 0.03) conditions but did not differ significantly between the trained and detrained conditions in either the fasted or the postprandial states. These results suggest that, although fat ingestion induces endothelial dysfunction, interventions that alter postprandial TG metabolism will not necessarily concomitantly influence endothelial function.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Malkova, Dr Dale and Gill, Professor Jason and Caslake, Professor Muriel and Ferrell, Professor William
Authors: Gill, J.M.R., Caslake, M.J., McAllister, C., Tsofliou, F., Ferrell, W.R., Packard, C.J., and Malkova, D.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Clinical Specialities
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Clinical Endocrinology and Metabolism
ISSN:0021-972X
ISSN (Online):1945-7197
Published Online:02 July 2003

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