Stanley, A.J. , Forrest, E.H., Dabos, K.J., MacGilchrist, A.J. and Hayes, P.C. (1998) Comparison between theophylline and spironolactone in the management of cirrhotic ascites: a randomized controlled study. Alimentary Pharmacology and Therapeutics, 12(4), pp. 389-393. (doi: 10.1046/j.1365-2036.1998.00318.x) (PMID:9690731)
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Abstract
Background: It has been suggested that adenosine is involved in the renal haemodynamic and tubular abnormalities observed in cirrhosis. Low-dose theophylline is an adenosine antagonist: and recent studies have shown that this drug can improve renal blood flow and sodium excretion in cirrhotic patients. Methods: Fifteen patients with newly diagnosed cirrhotic ascites were randomized to receive either 100 mg spironolactone daily for 7 days or 250 mg theophylline on days 1, 2, 4 and 6. Baseline clinical and urinary and serum biochemical data were collected and compared following therapy. Results: After 7 days of spironolactone there were increases in urinary sodium excretion (43.5 ± 15.6 vs. 106.8 ± 34.7 mmol/day; P < 0.05) and urine volume (769.1 ± 206.5 vs 1541.6 ± 342.6 mL/day; P < 0.05). No changes in the patients' weight, creatinine clearance or serum electrolytes were observed. No change was detected in any of these parameters following theophylline therapy. Conclusion: Adenosine antagonism in the form of low-dose theophylline is less efficacious than spironolactone in the management of cirrhotic ascites.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Stanley, Dr Adrian and Forrest, Dr Ewan |
| Authors: | Stanley, A.J., Forrest, E.H., Dabos, K.J., MacGilchrist, A.J., and Hayes, P.C. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | Alimentary Pharmacology and Therapeutics |
| Publisher: | Wiley-Blackwell Publishing Ltd. |
| ISSN: | 0269-2813 |
| ISSN (Online): | 1365-2036 |
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