Minimal deviation Barrett's adenocarcinoma: a diagnostic challenge

Atwan, M., Stanley, A. J. and Going, J. J. (2011) Minimal deviation Barrett's adenocarcinoma: a diagnostic challenge. Diagnostic Histopathology, 17(5), pp. 238-242. (doi: 10.1016/j.mpdhp.2011.02.003)

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Barrett’s oesophagus is the major risk factor for oesophageal adenocarcinoma. The purpose of Barrett’s surveillance is to detect progression of neoplasia at an early, treatable stage. We report progression in a 60-year-old male of an exceptionally well differentiated oesophageal adenocarcinoma to pT3 pN1 despite surveillance. Extremely well differentiated Barrett’s adenocarcinoma has some similarity with adenoma malignum of the uterine cervix. Lack of glandular maturation, loss of mucosal polarization and glands in unusual loci are clues to the diagnosis in a background of Barrett’s dysplasia. The role of surveillance endoscopy for Barrett’s oesophagus remains controversial, but this case emphasizes the need for high quality histopathology and clinical correlation when Barrett’s surveillance is undertaken.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Stanley, Dr Adrian and Going, Dr James
Authors: Atwan, M., Stanley, A. J., and Going, J. J.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Diagnostic Histopathology
Published Online:17 March 2011

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