Al Murri, A.M., Wilson, C., Lannigan, A., Doughty, J.C., Angerson, W.J., McArdle, C.S. and McMillan, D.C. (2007) Evaluation of the relationship between the systemic inflammatory response and cancer-specific survival in patients with primary operable breast cancer. British Journal of Cancer, 96, pp. 891-895. (doi: 10.1038/sj.bjc.6603682)
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Abstract
The relationship between the systemic inflammatory response (as evidenced by elevated C-reactive protein and lowered albumin concentrations), clinico-pathologic status and relapse-free, cancer-specific and overall survival was examined in patients with invasive primary operable breast cancer (n=300). The median follow-up of the survivors was 46 months. During this period, 37 patients relapsed and 25 died of their cancer. On multivariate analysis, only tumour size (P<0.05), albumin (P<0.01) and systemic treatment (P<0.0001) were significant independent predictors of relapse-free, cancer-specific and overall survival. Lower serum albumin concentrations (less than or equal to43 g l-1) were associated with deprivation (P<0.05), hormonal receptor negative tumours (P<0.01) and significantly poorer 3-year relapse-free (85 vs 93%, P=0.001) cancer-specific (87 vs 97%, P<0.0001) and overall survival (84 vs 94%, P=0.001) rates. The results of the present study suggest that lower preoperative albumin concentrations, but not elevated C-reactive protein concentrations, predict relapse-free, cancer-specific and overall survival, independent of clinico-pathologic status and treatment in patients undergoing potentially curative surgery for primary operable breast cancer.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Angerson, Dr Wilson and McMillan, Professor Donald and Doughty, Miss Julie |
Authors: | Al Murri, A.M., Wilson, C., Lannigan, A., Doughty, J.C., Angerson, W.J., McArdle, C.S., and McMillan, D.C. |
College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Clinical Specialities |
Journal Name: | British Journal of Cancer |
ISSN: | 0007-0920 |
Published Online: | 20 March 2007 |
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