Evaluation of the relationship between the systemic inflammatory response and cancer-specific survival in patients with primary operable breast cancer

Al Murri, A.M., Wilson, C., Lannigan, A., Doughty, J.C., Angerson, W.J., McArdle, C.S. and McMillan, D.C. (2007) Evaluation of the relationship between the systemic inflammatory response and cancer-specific survival in patients with primary operable breast cancer. British Journal of Cancer, 96, pp. 891-895. (doi:10.1038/sj.bjc.6603682)

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Abstract

The relationship between the systemic inflammatory response (as evidenced by elevated C-reactive protein and lowered albumin concentrations), clinico-pathologic status and relapse-free, cancer-specific and overall survival was examined in patients with invasive primary operable breast cancer (n=300). The median follow-up of the survivors was 46 months. During this period, 37 patients relapsed and 25 died of their cancer. On multivariate analysis, only tumour size (P<0.05), albumin (P<0.01) and systemic treatment (P<0.0001) were significant independent predictors of relapse-free, cancer-specific and overall survival. Lower serum albumin concentrations (less than or equal to43 g l-1) were associated with deprivation (P<0.05), hormonal receptor negative tumours (P<0.01) and significantly poorer 3-year relapse-free (85 vs 93%, P=0.001) cancer-specific (87 vs 97%, P<0.0001) and overall survival (84 vs 94%, P=0.001) rates. The results of the present study suggest that lower preoperative albumin concentrations, but not elevated C-reactive protein concentrations, predict relapse-free, cancer-specific and overall survival, independent of clinico-pathologic status and treatment in patients undergoing potentially curative surgery for primary operable breast cancer.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Angerson, Dr Wilson and McMillan, Professor Donald and Doughty, Miss Julie
Authors: Al Murri, A.M., Wilson, C., Lannigan, A., Doughty, J.C., Angerson, W.J., McArdle, C.S., and McMillan, D.C.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Clinical Specialities
Journal Name:British Journal of Cancer
ISSN:0007-0920
Published Online:20 March 2007

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