Refugia and anthelmintic resistance: concepts and challenges

Hodgkinson, J. E. et al. (2019) Refugia and anthelmintic resistance: concepts and challenges. International Journal for Parasitology, 10, pp. 51-57. (doi:10.1016/j.ijpddr.2019.05.001) (PMID:31125837) (PMCID:PMC6531808)

Hodgkinson, J. E. et al. (2019) Refugia and anthelmintic resistance: concepts and challenges. International Journal for Parasitology, 10, pp. 51-57. (doi:10.1016/j.ijpddr.2019.05.001) (PMID:31125837) (PMCID:PMC6531808)

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Abstract

Anthelmintic resistance is a threat to global food security. In order to alleviate the selection pressure for resistance and maintain drug efficacy, management strategies increasingly aim to preserve a proportion of the parasite population in ‘refugia’, unexposed to treatment. While persuasive in its logic, and widely advocated as best practice, evidence for the ability of refugia-based approaches to slow the development of drug resistance in parasitic helminths is currently limited. Moreover, the conditions needed for refugia to work, or how transferable those are between parasite-host systems, are not known. This review, born of an international workshop, seeks to deconstruct the concept of refugia and examine its assumptions and applicability in different situations. We conclude that factors potentially important to refugia, such as the fitness cost of drug resistance, the degree of mixing between parasite sub-populations selected through treatment or not, and the impact of parasite life-history, genetics and environment on the population dynamics of resistance, vary widely between systems. The success of attempts to generate refugia to limit anthelmintic drug resistance are therefore likely to be highly dependent on the system in hand. Additional research is needed on the concept of refugia and the underlying principles for its application across systems, as well as empirical studies within systems that prove and optimise its usefulness.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Devaney, Professor Eileen and Mable, Professor Barbara and McIntyre, Miss Jennifer and Britton, Dr Collette and Morrison, Dr Thomas and Matthews, Professor Louise and Laing, Dr Rosalind and Prentice, Dr Jamie and Babayan, Dr Simon
Authors: Hodgkinson, J. E., Kaplan, R. M., Kenyon, F., Morgan, E. R., Park, A. W., Paterson, S., Babayan, S. A., Beesley, N. J., Britton, C., Chaudhry, U., Doyle, S. R., Ezenwa, V. O., Fenton, A., Howell, S. B., Laing, R., Mable, B. K., Matthews, L., McIntyre, J., Milne, C. E., Morrison, T. A., Prentice, J., Sargison, N. D., Williams, D. J.L., Wolstenholme, A. J., and Devaney, E.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
Journal Name:International Journal for Parasitology
Publisher:Elsevier
ISSN:0020-7519
ISSN (Online):2211-3207
Published Online:17 May 2019
Copyright Holders:Copyright © 2019 Elsevier Ltd.
First Published:First published in International Journal for Parasitology: Drugs and Drug Resistance 10:51-57
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
724091United States-UK partnering award:Co-infection and resistance (CORE)Eileen DevaneyBiotechnology and Biological Sciences Research Council (BBSRC)BB/N022386/1RI BIODIVERSITY ANIMAL HEALTH & COMPMED