The associations between self-reported depression, self-reported chronic inflammatory conditions and cognitive abilities in UK Biobank

Lyall, L. M., Cullen, B. , Lyall, D. M. , Leighton, S. P. , Siebert, S. , Smith, D. J. and Cavanagh, J. (2019) The associations between self-reported depression, self-reported chronic inflammatory conditions and cognitive abilities in UK Biobank. European Psychiatry, 60, pp. 63-70. (doi: 10.1016/j.eurpsy.2019.05.007) (PMID:31158611) (PMCID:PMC6669333)

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Background: Depression and chronic inflammatory medical conditions have been linked to impaired cognitive ability. However despite frequent comorbidity, their combined association with cognitive ability has rarely been examined. Methods: This study examined associations between self-reported depression and chronic inflammatory diseases and their interaction with cognitive performance in 456,748 participants of the UK Biobank, adjusting for sociodemographic and lifestyle factors. Numbers with available data ranged from 94,899 to 453,208 depending on the cognitive test. Results: Self-reported depression was associated with poorer performance compared to controls in several cognitive tests (fully adjusted models, reaction time: B = 6.08, 95% CI = 5.09, 7.07; pairs matching: incidence rate ratio = 1.02, 95% CI = 1.02, 1.03; Trail Making Test B: B = 1.37, 95% CI = 0.88, 1.87; Digit Symbol Substitution Test (DSST): B = −0.35, 95% CI = −0.44, −0.27). Self-reported chronic inflammatory conditions were associated with slower reaction time (B = 3.79, 95% CI = 2.81, 4.78) and lower DSST scores (B = −0.21, 95% CI = −0.30, −0.13). No interaction effects were observed. Discussion: In this large, population-based study we provide evidence of lower cognitive performance in both depression and a comprehensive category of chronic inflammatory conditions. Results are consistent with additive effects of both types of disorder on cognitive ability. Clinicians should be aware of such effects, particularly as cognitive impairment is linked to poorer disease outcomes and quality of life.

Item Type:Articles
Additional Information:This research was conducted using the UK Biobank resource, under application 17689 (PI Lyall). UK Biobank was established by the Wellcome Trust, Medical Research Council, Department of Health, Scottish Government and Northwest Regional Development Agency. UK Biobank has also had funding from the Welsh Assembly Government and the British Heart Foundation. Data collection was funded by UK Biobank. JC acknowledges the support of The Sackler Trust and is part of the Wellcome Trust funded Neuroimmunology of Mood and Alzheimer’s consortium (104025/ Z/14/Z) that includes collaboration with GSK, Lundbeck, Pfizer and Janssen & Janssen. DJS is supported by an Independent Investigator Award from the Brain and Behavior Research Foundation (21930) and a Lister Prize Fellowship (173096). DJS and LML are supported by an MRC Mental Health Data Pathfinder Award (reference MC_PC_17217).
Glasgow Author(s) Enlighten ID:Smith, Professor Daniel and Cullen, Dr Breda and Lyall, Dr Laura and Siebert, Professor Stefan and Cavanagh, Professor Jonathan and Leighton, Dr Samuel and Lyall, Dr Donald
Authors: Lyall, L. M., Cullen, B., Lyall, D. M., Leighton, S. P., Siebert, S., Smith, D. J., and Cavanagh, J.
College/School:College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Mental Health and Wellbeing
College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health
College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:European Psychiatry
Publisher:Elsevier Masson SAS
ISSN (Online):1778-3585
Copyright Holders:Copyright © 2019 The Authors
First Published:First published in European Psychiatry 60:63-70
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
657471Consortium of Neuroimmunology of Mood Disorders and Alzheimer's DiseaseJonathan CavanaghWellcome Trust (WELLCOTR)104025/Z/14/ZIHW - MENTAL HEALTH & WELLBEING
3029570Mental Health Data PathfinderDaniel SmithMedical Research Council (MRC)MC_PC_17217HW - Mental Health and Wellbeing