Calcium buffering in the heart in health and disease

Smith, G. L. and Eisner, D. A. (2019) Calcium buffering in the heart in health and disease. Circulation, 139(20), pp. 2358-2371. (doi: 10.1161/circulationaha.118.039329) (PMID:31082292)

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Abstract

Changes of intracellular Ca2+ concentration regulate many aspects of cardiac myocyte function. About 99% of the cytoplasmic calcium in cardiac myocytes is bound to buffers, and their properties will therefore have a major influence on Ca2+ signaling. This article considers the fundamental properties and identities of the buffers and how to measure them. It reviews the effects of buffering on the systolic Ca2+ transient and how this may change physiologically, and in heart failure and both atrial and ventricular arrhythmias, as well. It is concluded that the consequences of this strong buffering may be more significant than currently appreciated, and a fuller understanding is needed for proper understanding of cardiac calcium cycling and contractility.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Smith, Professor Godfrey
Authors: Smith, G. L., and Eisner, D. A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Circulation
Publisher:American Heart Association
ISSN:0009-7322
ISSN (Online):1524-4539
Copyright Holders:Copyright © 2019 The Authors
First Published:First published in Circulation 139(20):2358-2371
Publisher Policy:Reproduced under a Creative Commons license

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
3003810Investigating the influence of myofibroblast coupling on cardiac conduction and infarct electrophysiologyGodfrey SmithBritish Heart Foundation (BHF)PG/17/12/32847CAMS - Cardiovascular Science