Brain volumetric changes and cognitive ageing during the eighth decade of life

Ritchie, S. J. et al. (2015) Brain volumetric changes and cognitive ageing during the eighth decade of life. Human Brain Mapping, 36(12), pp. 4910-4925. (doi: 10.1002/hbm.22959) (PMID:26769551) (PMCID:PMC4832269)

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Abstract

Later‐life changes in brain tissue volumes—decreases in the volume of healthy grey and white matter and increases in the volume of white matter hyperintensities (WMH)—are strong candidates to explain some of the variation in ageing‐related cognitive decline. We assessed fluid intelligence, memory, processing speed, and brain volumes (from structural MRI) at mean age 73 years, and at mean age 76 in a narrow‐age sample of older individuals (n = 657 with brain volumetric data at the initial wave, n = 465 at follow‐up). We used latent variable modeling to extract error‐free cognitive levels and slopes. Initial levels of cognitive ability were predictive of subsequent brain tissue volume changes. Initial brain volumes were not predictive of subsequent cognitive changes. Brain volume changes, especially increases in WMH, were associated with declines in each of the cognitive abilities. All statistically significant results were modest in size (absolute r‐values ranged from 0.114 to 0.334). These results build a comprehensive picture of macrostructural brain volume changes and declines in important cognitive faculties during the eighth decade of life.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Dickie, Dr David Alexander
Authors: Ritchie, S. J., Dickie, D. A., Cox, S. R., Valdes Hernandez, M. d. C., Corley, J., Royle, N. A., Pattie, A., Aribisala, B. S., Redmond, P., Muñoz Maniega, S., Taylor, A. M., Sibbett, R., Gow, A. J., Starr, J. M., Bastin, M. E., Wardlaw, J. M., and Deary, I. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Human Brain Mapping
Publisher:Wiley
ISSN:1065-9471
ISSN (Online):1097-0193
Published Online:07 September 2015
Copyright Holders:Copyright © 2015 The Authors
First Published:First published in Human Brain Mapping 36(12):4910-4925
Publisher Policy:Reproduced under a Creative Commons License

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