Neurological signs and MRI findings in 12 dogs with multiple myeloma

Wyatt, S., De Risio, L., Driver, C., Jose-Lopez, R. , Pivetta, M. and Beltran, E. (2019) Neurological signs and MRI findings in 12 dogs with multiple myeloma. Veterinary Radiology and Ultrasound, 60(4), pp. 409-415. (doi: 10.1111/vru.12759) (PMID:31056799)

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Abstract

Vertebral lesions and associated neurological signs occur in dogs with multiple myeloma, however, veterinary literature describing MRI findings is currently lacking. The objective of this multicenter, retrospective, case series study was to describe neurological signs and MRI findings in a group of dogs that presented for spinal pain or other neurological deficits and had multiple myeloma. Electronic records of four veterinary referral hospitals were reviewed. Dogs were included if they had a pathologically confirmed diagnosis of multiple myeloma, had presented for spinal pain or other neurological signs, and had undergone MRI of the vertebral column. The MRI studies were evaluated and the anatomical location of lesion(s), signal intensity, presence of extra-dural material, degree of spinal cord compression, extent of vertebral lesions, and contrast enhancement were recorded. Twelve dogs met inclusion criteria. Most dogs (n = 8) had a chronic progressive history, with varying degrees of proprioceptive ataxia and paresis (n = 11), and spinal pain was a feature in all dogs. The MRI findings were variable but more consistent features included the presence of multiple expansile vertebral lesions without extension beyond the outer cortical limits of affected vertebrae, and associated extradural material causing spinal cord compression. The majority of lesions were hyper- to isointense on T2 (n = 12) and T1-weighted (n = 8) sequences, with variable but homogeneous contrast-enhancement (n = 12). These described MRI characteristics of multiple myeloma may be used to aid early identification and guide subsequent confirmatory diagnostic steps, to ultimately improve therapeutic approach and long-term outcome.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Jose-Lopez, Mr Roberto
Authors: Wyatt, S., De Risio, L., Driver, C., Jose-Lopez, R., Pivetta, M., and Beltran, E.
College/School:College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
Journal Name:Veterinary Radiology and Ultrasound
Publisher:Wiley
ISSN:1058-8183
ISSN (Online):1740-8261
Published Online:06 May 2019
Copyright Holders:Copyright © 2019 American College of Veterinary Radiology
First Published:First published in Veterinary Radiology and Ultrasound 60(4): 409-415
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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