Queirazza, F., Fouragnan, E., Steele, J. D., Cavanagh, J. and Philiastides, M. G. (2019) Neural correlates of weighted reward prediction error during reinforcement learning classify response to cognitive behavioral therapy in depression. Science Advances, 5(7), eaav4962. (doi: 10.1126/sciadv.aav4962) (PMID:31392266) (PMCID:PMC6669013)
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Abstract
While cognitive behavioral therapy (CBT) is an effective treatment for major depressive disorder, only up to 45% of depressed patients will respond to it. At present, there is no clinically viable neuroimaging predictor of CBT response. Notably, the lack of a mechanistic understanding of treatment response has hindered identification of predictive biomarkers. To obtain mechanistically meaningful fMRI predictors of CBT response, we capitalize on pretreatment neural activity encoding a weighted reward prediction error (RPE), which is implicated in the acquisition and processing of feedback information during probabilistic learning. Using a conventional mass-univariate fMRI analysis, we demonstrate that, at the group level, responders exhibit greater pretreatment neural activity encoding a weighted RPE in the right striatum and right amygdala. Crucially, using multivariate methods, we show that this activity offers significant out-of-sample classification of treatment response. Our findings support the feasibility and validity of neurocomputational approaches to treatment prediction in psychiatry.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Queirazza, Dr Filippo and Fouragnan, Dr Elsa and Cavanagh, Professor Jonathan and Philiastides, Professor Marios |
Authors: | Queirazza, F., Fouragnan, E., Steele, J. D., Cavanagh, J., and Philiastides, M. G. |
College/School: | College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Mental Health and Wellbeing College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience |
Research Centre: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Immunobiology |
Journal Name: | Science Advances |
Publisher: | American Association for the Advancement of Science |
ISSN: | 2375-2548 |
ISSN (Online): | 2375-2548 |
Published Online: | 31 July 2019 |
Copyright Holders: | Copyright © 2019 The Authors |
First Published: | First published in Science Advances 5(7): eaav4962 |
Publisher Policy: | Reproduced under a Creative Commons License |
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