Neural correlates of weighted reward prediction error during reinforcement learning classify response to cognitive behavioral therapy in depression

Queirazza, F., Fouragnan, E., Steele, J. D., Cavanagh, J. and Philiastides, M. G. (2019) Neural correlates of weighted reward prediction error during reinforcement learning classify response to cognitive behavioral therapy in depression. Science Advances, 5(7), eaav4962. (doi:10.1126/sciadv.aav4962) (PMID:31392266) (PMCID:PMC6669013)

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Abstract

While cognitive behavioral therapy (CBT) is an effective treatment for major depressive disorder, only up to 45% of depressed patients will respond to it. At present, there is no clinically viable neuroimaging predictor of CBT response. Notably, the lack of a mechanistic understanding of treatment response has hindered identification of predictive biomarkers. To obtain mechanistically meaningful fMRI predictors of CBT response, we capitalize on pretreatment neural activity encoding a weighted reward prediction error (RPE), which is implicated in the acquisition and processing of feedback information during probabilistic learning. Using a conventional mass-univariate fMRI analysis, we demonstrate that, at the group level, responders exhibit greater pretreatment neural activity encoding a weighted RPE in the right striatum and right amygdala. Crucially, using multivariate methods, we show that this activity offers significant out-of-sample classification of treatment response. Our findings support the feasibility and validity of neurocomputational approaches to treatment prediction in psychiatry.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Queirazza, Dr Filippo and Fouragnan, Dr Elsa and Cavanagh, Professor Jonathan and Philiastides, Dr Marios
Authors: Queirazza, F., Fouragnan, E., Steele, J. D., Cavanagh, J., and Philiastides, M. G.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Mental Health and Wellbeing
College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Science Advances
Publisher:American Association for the Advancement of Science
ISSN:2375-2548
ISSN (Online):2375-2548
Published Online:31 July 2019
Copyright Holders:Copyright © 2019 The Authors
First Published:First published in Science Advances 5(7): eaav4962
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
653861Spatiotemporal characterization of value judgments and reward processing in the human brainMarios PhiliastidesBiotechnology and Biological Sciences Research Council (BBSRC)BB/J015393/2INP - CENTRE FOR COGNITIVE NEUROIMAGING
654411Neural correlates of learning and confidence during decision making and their utility in developing "intelligent technologies".Marios PhiliastidesEconomic and Social Research Council (ESRC)ES/L012995/1INP - CENTRE FOR COGNITIVE NEUROIMAGING

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