Cognitive abilities, brain white matter hyperintensity volume, and structural network connectivity in older age

Wiseman, S. J. et al. (2018) Cognitive abilities, brain white matter hyperintensity volume, and structural network connectivity in older age. Human Brain Mapping, 39(2), pp. 622-632. (doi: 10.1002/hbm.23857) (PMID:29139161) (PMCID:PMC5813175)

[img]
Preview
Text
186662.pdf - Published Version
Available under License Creative Commons Attribution.

547kB

Abstract

Objective: To assess brain structural connectivity in relation to cognitive abilities in healthy ageing, and the mediating effects of white matter hyper‐intensity (WMH) volume. Methods: MRI data were analysed in 558 members of the Lothian Birth Cohort 1936. Brains were segmented into 85 regions and combined with tractography to generate structural connectomes. WMH volume was quantified. Relationships between whole‐brain connectivity, assessed using graph theory metrics, and four major domains of cognitive ability (visuospatial reasoning, verbal memory, information processing speed and crystallized ability) were investigated, as was the mediating effects of WMH volume on these relationships. Results: Visuospatial reasoning was associated with network strength, mean shortest path length, and global efficiency. Memory was not associated with any network connectivity metric. Information processing speed and crystallized ability were associated with all network measures. Some relationships were lost when adjusted for mean network FA. WMH volume mediated 11%–15% of the relationships between most network measures and information processing speed, even after adjusting for mean network FA. Conclusion: Brain structural connectivity relates to visuospatial reasoning, information processing speed and crystallized ability, but not memory, in this relatively healthy age‐homogeneous cohort of 73 year olds. When adjusted for mean FA across the network, most relationships are lost, except with information processing speed suggesting that the underlying topological network structure is related to this cognitive domain. Moreover, the connectome‐processing speed relationship is partly mediated by WMH volume in this cohort.

Item Type:Articles
Additional Information:Contract grant sponsor: Research into Ageing Programme; Con- tract grant sponsor: Age UK-funded Disconnected Mind project; Contract grant sponsor: UK Medical Research Council; Contract grant numbers: G0701120, G1001245, and MR/M013111/1; Con- tract grant sponsor: Scottish Funding Council through the SINAPSE Collaboration (Scottish Imaging Network–A Platform for Scientific Evidence; Contract grant sponsor: BBSRC; Contract grant sponsor: MRC; Contract grant numbers: MRC MR/ K026992/1; Contract grant sponsor: Row Fogo Charitable Trust; Contract grant numbers: BRO-D.FID3668413.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Dickie, Dr David Alexander
Authors: Wiseman, S. J., Booth, T., Ritchie, S. J., Cox, S. R., Muñoz Maniega, S., Valdés Hernández, M. d. C., Dickie, D. A., Royle, N. A., Starr, J. M., Deary, I. J., Wardlaw, J. M., and Bastin, M. E.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Human Brain Mapping
Publisher:Wiley
ISSN:1065-9471
ISSN (Online):1097-0193
Published Online:14 November 2017
Copyright Holders:Copyright © 2017 The Authors
First Published:First published in Human Brain Mapping 39(2):622-632
Publisher Policy:Reproduced under a Creative Commons License

University Staff: Request a correction | Enlighten Editors: Update this record