Martinez Corrales, G., Cabrero, P. , Dow, J. A.T. , Terhzaz, S. and Davies, S. (2019) Novel roles for GATAe in growth, maintenance and proliferation of cell populations in the Drosophila renal tubule. Development, 146(9), dev178087. (doi: 10.1242/dev.178087) (PMID:31036543)
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Abstract
The GATA family of transcription factors is implicated in numerous developmental and physiological processes in metazoans. In Drosophila melanogaster, five different GATA factor genes (pannier, serpent, grain, GATAd and GATAe) have been reported as essential in the development and identity of multiple tissues, including the midgut, heart and brain. Here, we present a novel role for GATAe in the function and homeostasis of the Drosophila renal (Malpighian) tubule. We demonstrate that reduced levels of GATAe gene expression in tubule principal cells induce uncontrolled cell proliferation, resulting in tumorous growth with associated altered expression of apoptotic and carcinogenic key genes. Furthermore, we uncover the involvement of GATAe in the maintenance of stellate cells and migration of renal and nephritic stem cells into the tubule. Our findings of GATAe as a potential master regulator in the events of growth control and cell survival required for the maintenance of the Drosophila renal tubule could provide new insights into the molecular pathways involved in the formation and maintenance of a functional tissue and kidney disease.
| Item Type: | Articles |
|---|---|
| Keywords: | Drosophila, GATAe, maintenance, Malpighian tubules, migration, principal and stellate cells, proliferation, renal stem cells. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Cabrero, Mr Pablo and Dow, Professor Julian and Terhzaz, Dr Selim and Davies, Professor Shireen and Martinez Corrales, Guillermo |
| Authors: | Martinez Corrales, G., Cabrero, P., Dow, J. A.T., Terhzaz, S., and Davies, S. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
| Journal Name: | Development |
| Publisher: | Company of Biologists |
| ISSN: | 0950-1991 |
| ISSN (Online): | 1477-9129 |
| Published Online: | 09 May 2019 |
| Copyright Holders: | Copyright © 2019 The Company of Biologists Ltd |
| First Published: | First published in Development 146(9): dev178087 |
| Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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