Novel roles for GATAe in growth, maintenance and proliferation of cell populations in the Drosophila renal tubule

Martinez Corrales, G., Cabrero, P. , Dow, J. A.T. , Terhzaz, S. and Davies, S. (2019) Novel roles for GATAe in growth, maintenance and proliferation of cell populations in the Drosophila renal tubule. Development, 146(9), dev178087. (doi:10.1242/dev.178087) (PMID:31036543)

Martinez Corrales, G., Cabrero, P. , Dow, J. A.T. , Terhzaz, S. and Davies, S. (2019) Novel roles for GATAe in growth, maintenance and proliferation of cell populations in the Drosophila renal tubule. Development, 146(9), dev178087. (doi:10.1242/dev.178087) (PMID:31036543)

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Abstract

The GATA family of transcription factors is implicated in numerous developmental and physiological processes in metazoans. In Drosophila melanogaster, five different GATA factor genes (pannier, serpent, grain, GATAd and GATAe) have been reported as essential in the development and identity of multiple tissues, including the midgut, heart and brain. Here, we present a novel role for GATAe in the function and homeostasis of the Drosophila renal (Malpighian) tubule. We demonstrate that reduced levels of GATAe gene expression in tubule principal cells induce uncontrolled cell proliferation, resulting in tumorous growth with associated altered expression of apoptotic and carcinogenic key genes. Furthermore, we uncover the involvement of GATAe in the maintenance of stellate cells and migration of renal and nephritic stem cells into the tubule. Our findings of GATAe as a potential master regulator in the events of growth control and cell survival required for the maintenance of the Drosophila renal tubule could provide new insights into the molecular pathways involved in the formation and maintenance of a functional tissue and kidney disease.

Item Type:Articles
Keywords:Drosophila, GATAe, maintenance, Malpighian tubules, migration, principal and stellate cells, proliferation, renal stem cells.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Cabrero, Mr Pablo and Dow, Professor Julian and Terhzaz, Dr Selim and Davies, Professor Shireen and Martinez Corrales, Guillermo
Authors: Martinez Corrales, G., Cabrero, P., Dow, J. A.T., Terhzaz, S., and Davies, S.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:Development
Publisher:Company of Biologists
ISSN:0950-1991
ISSN (Online):1477-9129
Published Online:09 May 2019
Copyright Holders:Copyright © 2019 The Company of Biologists Ltd
First Published:First published in Development 146(9): dev178087
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
669961RENALTRACTShireen DaviesEuropean Commission (EC)642937RI MOLECULAR CELL & SYSTEMS BIOLOGY