Pentamidine uptake and resistance in pathogenic protozoa: past, present and future

Bray, P., Barrett, M. , Ward, S. and de Koning, H. (2003) Pentamidine uptake and resistance in pathogenic protozoa: past, present and future. Trends in Parasitology, 19(5), pp. 232-239. (doi:10.1016/S1471-4922(03)00069-2)

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Abstract

Diamidines, and pentamidine in particular, have a long history as valuable chemotherapeutic agents against infectious disease. Their selectivity is due mostly to selective accumulation by the pathogen, rather than the host cell; and acquired resistance is frequently the result of changes in transmembrane transport of the drug. Here, recent progress in elucidating the mechanisms of diamidine transport in three important protozoan pathogens, Trypanosoma brucei, Leishmania and Plasmodium falciparum, is reviewed, and the implications for drug resistance are discussed.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Barrett, Professor Michael and De Koning, Professor Harry
Authors: Bray, P., Barrett, M., Ward, S., and de Koning, H.
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Trends in Parasitology
ISSN:1471-4922

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