Bray, P., Barrett, M. , Ward, S. and de Koning, H. (2003) Pentamidine uptake and resistance in pathogenic protozoa: past, present and future. Trends in Parasitology, 19(5), pp. 232-239. (doi: 10.1016/S1471-4922(03)00069-2)
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Abstract
Diamidines, and pentamidine in particular, have a long history as valuable chemotherapeutic agents against infectious disease. Their selectivity is due mostly to selective accumulation by the pathogen, rather than the host cell; and acquired resistance is frequently the result of changes in transmembrane transport of the drug. Here, recent progress in elucidating the mechanisms of diamidine transport in three important protozoan pathogens, Trypanosoma brucei, Leishmania and Plasmodium falciparum, is reviewed, and the implications for drug resistance are discussed.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Barrett, Professor Michael and De Koning, Professor Harry |
| Authors: | Bray, P., Barrett, M., Ward, S., and de Koning, H. |
| College/School: | College of Medical Veterinary and Life Sciences College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Trends in Parasitology |
| ISSN: | 1471-4922 |
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