A 64x64 SPAD array for portable colorimetric sensing, fluorescence and X-ray imaging

Accarino, C. et al. (2019) A 64x64 SPAD array for portable colorimetric sensing, fluorescence and X-ray imaging. IEEE Sensors Journal, 19(17), pp. 7319-7327. (doi: 10.1109/JSEN.2019.2916424)

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We present the design and application of a 64x64 pixel SPAD array to portable colorimetric sensing, and fluorescence and x-ray imaging. The device was fabricated on an unmodified 180 nm CMOS process and is based on a square p+/n active junction SPAD geometry suitable for detecting green fluorescence emission. The stand-alone SPAD shows a photodetection probability greater than 60% at 5 V excess bias, with a dark count rate of less than 4 cps/µm2 and sub-ns timing jitter performance. It has a global shutter with an in-pixel 8-bit counter; four 5-bit decoders and two 64-to-1 multiplexer blocks allow the data to be read-out. The array of sensors was able to detect fluorescence from a fluorescein isothiocyanate (FITC) solution down to a concentration of 900 pM with a SNR of 9.8 dB. A colorimetric assay was performed on top of the sensor array with a limit of quantification of 3.1 µM. X-rays images, using energies ranging from 10 kVp to 100 kVp, of a lead grating mask were acquired without using a scintillation crystal.

Item Type:Articles
Additional Information:This work was supported by EPSRC CDT in Integrative Sensing and Measurement (EP/L016753/1).
Glasgow Author(s) Enlighten ID:Al-Rawhani, Dr Mohammed and Maneuski, Dr Dima and Cumming, Professor David and MELINO, GIANLUCA and Grant, Dr James and Shah, Dr Yash Diptesh and Mitra, Dr Srinjoy and Buttar, Professor Craig and Annese, Dr Valerio and Accarino, Mr Claudio and Giagkoulovits, Dr Christos
Authors: Accarino, C., Melino, G., Annese, V., Al-Rawhani, M. A., Shah, Y. D., Maneuski, D., Giagkoulovits, C., Grant, J. P., Mitra, S., Buttar, C., and Cumming, D. R.S.
College/School:College of Science and Engineering
College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering
College of Science and Engineering > School of Physics and Astronomy
Journal Name:IEEE Sensors Journal
ISSN (Online):1530-437X
Published Online:13 May 2019
Copyright Holders:Copyright © 2019 IEEE
First Published:First published in IEEE Sensors Journal 19(17):7319-7327
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
636381EPSRC Centre for Doctoral Training in Sensing and MeasurementAndrew HarveyEngineering and Physical Sciences Research Council (EPSRC)EP/L016753/1S&E P&A - PHYSICS & ASTRONOMY