Genetic aspects of stroke: Human and experimental studies

Carr, F., McBride, M. , Carswell, H., Graham, D., Strahorn, P., Clark, J., Charchar, F. and Dominiczak, A. (2002) Genetic aspects of stroke: Human and experimental studies. Journal of Cerebral Blood Flow and Metabolism, 22(7), pp. 767-773. (doi:10.1097/00004647-200207000-00001)

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Abstract

As one of the leading causes of death within both the developed and developing world, stroke is a worldwide problem. Risk factors can be identified and controlled at the level of lifestyle changes; however, genetic components of stroke have yet to be identified. The identification of such genetic components is critical in the understanding, diagnosis, and treatment of stroke in the future. This review focuses on the genetic determinants of stroke in both human and experimental systems. Mendelian disorders, candidate genes, and twin studies provide evidence for a strong genetic component of stroke. Genome-wide scanning in both human and animal models has led to the identification of regions of the genome that contain genes for stroke susceptibility and sensitivity. Animal models of stroke allow for environmental control and genetic homogeneity, not possible within a human population, and therefore are essential for the dissection of this complex, multifactorial disorder. Future genetic and genomic strategies and their role in ultimate causative gene identification are discussed.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Clark, Dr John and McBride, Dr Martin and Dominiczak, Professor Anna
Authors: Carr, F., McBride, M., Carswell, H., Graham, D., Strahorn, P., Clark, J., Charchar, F., and Dominiczak, A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Clinical Specialities
Journal Name:Journal of Cerebral Blood Flow and Metabolism
Publisher:Nature Publishing Group
ISSN:0271-678X

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