Normobaric hyperoxia reduces cardiac index in patients after coronary artery bypass surgery

Harten, J.M., Anderson, K.J., Kinsella, J. and Higgins, M.J. (2005) Normobaric hyperoxia reduces cardiac index in patients after coronary artery bypass surgery. Journal of Cardiothoracic and Vascular Anesthesia, 19(2), pp. 173-175. (doi:10.1053/j.jvca.2004.11.053)

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Abstract

Objective: The purpose of this study was to assess the hemodynamic changes in response to normobaric hyperoxia in patients immediately after coronary artery bypass surgery. Design: Observational study. Setting: Single-center university hospital. Participants: Patients immediately after coronary artery bypass surgery. Intervention: Change of fractional inspired oxygen concentration from baseline (<= 0.60) to 1.0 and return to baseline. Measurements and Main Results: Cardiovascular changes were assessed with a lithium dilution technique. Cardiac index decreased from 2.82 to 2.52 L/min/m(2) (10.6%). Heart rate decreased from 85.9 to 82.5 beats/min (4.0%), and the systemic vascular resistance index increased from 1,858 to 2,304 dyne/s/cm(5)/m(2) (24.1%). Stroke index or mean arterial pressure did not change significantly. On reducing the F1O2 from 1.0 to the baseline F1O2, there was significant reversal of the previous changes in heart rate and systemic vascular resistance. Heart rate increased from 82.5 to 84.0 beats/min (1.8%), and the systemic vascular index decreased from 2304 to 1932 dyne/s/cm(5)/m(2) (16.1%). The cardiac output did not return to baseline, and the mean arterial pressure decreased from 69.6 to 64.4 mmHg (7.6%). Conclusions: Exposing patients after coronary artery surgery to hyperoxia induces significant hemodynamic changes.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Harten, Dr Johann and Kinsella, Professor John and Anderson, Dr Keith
Authors: Harten, J.M., Anderson, K.J., Kinsella, J., and Higgins, M.J.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Clinical Specialities
Journal Name:Journal of Cardiothoracic and Vascular Anesthesia
ISSN:1053-0770

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