Taming combinatorial explosion of the formose reaction via recursion within mineral environments

Cronin, L. , Colón-Santos, S. and Cooper, G. (2019) Taming combinatorial explosion of the formose reaction via recursion within mineral environments. ChemSystemsChem, 1, e1900014. (doi:10.1002/syst.201900014)

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Abstract

One‐pot reactions of simple precursors, such as those found in the formose reaction or formamide condensation, continuously lead to combinatorial explosions in which simple building blocks capable of function exist, but are in insufficient concentration to self‐organize, adapt, and thus generate complexity. We set out to explore the effect of recursion on such complex mixtures by ‘seeding’ the product mixture into a fresh version of the reaction, with the inclusion of different mineral environments, over a number of reaction cycles. Through untargeted UPLC‐HRMS analysis of the mixtures we found that the overall number of products detected reduces as the number of cycles increases, as a result of recursively enhanced mineral environment selectivity, thus limiting the combinatorial explosion. This discovery demonstrates how the involvement of mineral surfaces with simple reactions could lead to the emergence of some building blocks found in RNA, Ribose and Uracil, under much simpler conditions that originally thought.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Cooper, Dr Geoff and Colon Santos, Ms Stephanie and Cronin, Professor Lee
Authors: Cronin, L., Colón-Santos, S., and Cooper, G.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:ChemSystemsChem
Publisher:Wiley
ISSN:2570-4206
ISSN (Online):2570-4206
Published Online:30 April 2019
Copyright Holders:Copyright © 2019 The Authors
First Published:First published in ChemSystemsChem 1:e1900014
Publisher Policy:Reproduced under a Creative Commons license

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
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633821A Digital DNA Nano Writer (DNA NanoFab)Leroy CroninEngineering and Physical Sciences Research Council (EPSRC)EP/L015668/1CHEM - CHEMISTRY
646611Programmable 'Digital' Synthesis for Discovery and Scale-up of Molecules, Clusters and NanomaterialsLeroy CroninEngineering and Physical Sciences Research Council (EPSRC)EP/L023652/1CHEM - CHEMISTRY
561223Plug'n Play Photosynthetic for Rubisco Independent FuelsLeroy CroninBiotechnology and Biological Sciences Research Council (BBSRC)BB/M011267/1CHEM - CHEMISTRY
685741SMARTPOM: Artificial-Intelligence Driven Discovery and Synthesis of Polyoxometalate ClustersLeroy CroninEuropean Research Council (ERC)670467CHEM - CHEMISTRY
736221A molecular complexity approach to identifying bio-signatures, shadow-life, and new life formsLeroy CroninJohn Templeton Foundation (TEMPLFOU)60625CHEM - CHEMISTRY

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