The cost-effectiveness of outpatient (at home) cervical ripening with isosorbide mononitrate prior to induction of labour

Eddama, O., Petrou, S., Schroeder, L., Bollapragada, S., MacKenzie, F., Norrie, J., Reid, M. and Norman, J. (2009) The cost-effectiveness of outpatient (at home) cervical ripening with isosorbide mononitrate prior to induction of labour. BJOG: An International Journal of Obstetrics and Gynaecology, 116(9), pp. 1196-1203. (doi: 10.1111/j.1471-0528.2009.02236.x)

Abstract

Objectives To assess the cost-effectiveness of outpatient (at home) cervical ripening with isosorbide mononitrate (IMN) prior to induction of labour. Design Economic evaluation was conducted alongside a randomised placebo controlled trial (the IMOP trial). Setting Large UK maternity hospital. Population A total of 350 nulliparous women with a singleton pregnancy, cephalic presentation >= 37 weeks gestation, requiring cervical ripening prior to induction of labour. Interventions Isosorbide mononitrate (n = 177) or placebo (n = 173) self-administered vaginally at home at 48, 32 and 16 hours prior to the scheduled time of admission for induction. Results Mean health service costs between the period of randomisation and discharge for mother and infant were 1254.86 pound in the IMN group and 1242.88 pound in the placebo group, generating a mean cost difference of 11.98 pound (bootstrap mean cost difference 12.86; pound 95%CI: -106.79 pound, 129.39) pound that was not statistically significant (P = 0.842). The incremental cost per hour prevented from hospital admission to delivery was 7.53 pound. At the notional willingness to pay threshold of 100 pound per hour prevented from hospital admission to delivery, the probability that IMN is cost-effective was estimated at 0.67. This translated into a mean net monetary benefit of 98.13 pound for each woman given IMN. Conclusions Although the probability that IMN is cost-effective approaches 0.7 at seemingly low willingness to pay thresholds for an hour prevented from hospital admission to delivery, our results should be viewed in the light of the clinical findings from the IMOP trial.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Norrie, Prof John and Reid, Professor Margaret and Norman, Professor Jane
• Authors: Eddama, O., Petrou, S., Schroeder, L., Bollapragada, S., MacKenzie, F., Norrie, J., Reid, M., and Norman, J.
• College/School: College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Robertson Centre; ?? 20206000 ??
• Journal Name: BJOG: An International Journal of Obstetrics and Gynaecology
• Publisher: Wiley-Blackwell Publishing Ltd.
• ISSN: 1470-0328
• ISSN (Online): 1471-0528