Angiotensin-converting enzyme gene polymorphism in coronary artery disease in north India

Agrawal, S., Singh, V. P., Tewari, S., Sinha, N., Ramesh, V., Agarwal, S., Gilmour, A. and Mastana, S. (2004) Angiotensin-converting enzyme gene polymorphism in coronary artery disease in north India. Indian Heart Journal, 56(1), pp. 44-46. (PMID:15129790)

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Abstract

Background: The aim of this study was to investigate the role of angiotensin-converting enzyme gene polymorphism in patients with coronary artery disease in north India. Methods and Results: One hundred forty-six patients with angiographically proven atherosclerotic coronary artery disease, and 146 age- and sex-matched control subjects (treadmill-negative) were included in the study. Genomic DNA was extracted and analyzed for angiotensin-converting enzyme insertion/deletion polymorphism. Two independent investigators scored the genotypes. Conclusions: When we compared the genotypes of patients with coronary artery disease with those of normal controls, it was seen that all three genotypes, i.e. DD, ID and II, were not statistically different among patients and controls. Further, we categorized the patient and control groups into 2 subgroups, i.e. below and above 50 years of age. Interestingly, it was observed that the DD genotype was significantly higher in patients in the higher age group (i.e. above 50 years of age). However, this needs further validation by studying patients with coronary artery disease from other parts of India.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Gilmour, Miss Ashley
Authors: Agrawal, S., Singh, V. P., Tewari, S., Sinha, N., Ramesh, V., Agarwal, S., Gilmour, A., and Mastana, S.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Indian Heart Journal
Publisher:Elsevier
ISSN:0019-4832
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