A variant of position −308 of the Tumour necrosis factor alpha gene promoter and the risk of coronary heart disease

Elahi, M. M., Gilmour, A., Matata, B. M. and Mastana, S. S. (2008) A variant of position −308 of the Tumour necrosis factor alpha gene promoter and the risk of coronary heart disease. Heart, Lung and Circulation, 17(1), pp. 14-18. (doi: 10.1016/j.hlc.2007.05.009) (PMID:17581788)

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Abstract

Purpose: The aim of this study was to investigate whether the variability between individuals with coronary heart disease (CHD) is related to the prevalence of TNF-α gene promoter −308 variant in un-matched British Caucasian population from East Midlands. Procedures: Genotypes and allele frequencies were determined using restriction fragment length polymorphism analysis of polymerase chain reaction (PCR) products. Genomic DNA prepared from peripheral blood leukocytes of patients (n = 97) and healthy controls (n = 95) demonstrated two alleles TNF*1 (G) and TNF*2 (A). Findings: The genotype distribution in patients was GG, n = 59; GA, n = 36; and AA, n = 2 and in controls was GG, n = 41; GA, n = 40; and AA, n = 14 (P = 0.014). The association analysis demonstrated that TNF*1 allele in patients appears to be associated with greater incidences of CHD (OR 2.15; CI, 1.36–3.39; P = 0.001). Conclusions: Our results suggest that TNF*1 allele (TNF-α −308 GG or GA) has a high prevalence among British Caucasian population that correlates with an increased CHD risk.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Gilmour, Miss Ashley
Authors: Elahi, M. M., Gilmour, A., Matata, B. M., and Mastana, S. S.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Heart, Lung and Circulation
Publisher:Elsevier
ISSN:1443-9506
Published Online:19 June 2007

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