Association of PTPN22 with rheumatoid arthritis among South Asians in the UK

Mastana, S., Gilmour, A., Ghelani, A., Smith, H. and Samanta, A. (2007) Association of PTPN22 with rheumatoid arthritis among South Asians in the UK. Journal of Rheumatology, 34(10), pp. 1984-1986. (PMID:17696275)

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Publisher's URL: http://www.jrheum.org/content/34/10/1984

Abstract

Objective: To compare the distribution and assess genetic associations of the PTPN22 R620W single-nucleotide polymorphism among South Asian (Asiatic Indian) patients with rheumatoid arthritis (RA) and ethnically matched controls. Methods: DNA samples from 133 rheumatoid factor-positive South Asian RA patients and 149 control subjects from the East Midlands of the UK were genotyped for PTPN22 R620W polymorphism. Genotyping was performed by the polymerase chain reaction-restriction fragment length polymorphism method. Results: The PTPN22 *T allele frequency was lower than in the Caucasian populations, but the disease association was significant (odds ratio 5.87, 95% confidence interval 1.68-20.52). Similar association was observed for genotypes containing *T allele. Conclusion: Our results suggest that the T variant acts as a susceptibility allele for autoantibody-positive RA among South Asians.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Gilmour, Miss Ashley
Authors: Mastana, S., Gilmour, A., Ghelani, A., Smith, H., and Samanta, A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Rheumatology
Publisher:Journal of Rheumatology
ISSN:0315-162X

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