Revisiting gametocyte biology in malaria parasites

Ngotho, P., Blancke Soares, A., Hentzschel, F., Achcar, F. , Bertuccini, L. and Marti, M. (2019) Revisiting gametocyte biology in malaria parasites. FEMS Microbiology Reviews, 43(4), pp. 401-414. (doi:10.1093/femsre/fuz010) (PMID:31220244) (PMCID:PMC6606849)

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Abstract

Gametocytes are the only form of the malaria parasite that is transmissible to the mosquito vector. They are present at low levels in blood circulation and significant knowledge gaps exist in their biology. Recent reductions in the global malaria burden have brought the possibility of elimination and eradication, with renewed focus on malaria transmission biology as a basis for interventions. This review discusses recent insights into gametocyte biology in the major human malaria parasite, Plasmodium falciparum and related species.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Achcar, Dr Fiona and Hentzschel, Dr Franziska and Blancke Soares, Dr Alexandra and Ngotho, Dr Priscilla and Marti, Professor Matthias
Authors: Ngotho, P., Blancke Soares, A., Hentzschel, F., Achcar, F., Bertuccini, L., and Marti, M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:FEMS Microbiology Reviews
Publisher:Oxford University Press
ISSN:0168-6445
ISSN (Online):1574-697
Published Online:09 April 2019
Copyright Holders:Copyright © 2019 FEMS
First Published:First published in FEMS Microbiology Reviews 43(4):401-414
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
711751Elucidating mechanisms of extracellular vesiclemediated cellular communication and stage conversion in malaria parasites.Matthias MartiWellcome Trust (WELLCOTR)110166/B/15/ZIII - PARASITOLOGY
371799The Wellcome Centre for Molecular Parasitology ( Core Support )Andrew WatersWellcome Trust (WELLCOTR)104111/Z/14/Z & AIII - PARASITOLOGY
699811BoneMalarMatthias MartiEuropean Research Council (ERC)682360III - PARASITOLOGY