Animal models of rheumatoid arthritis

Asquith, D. L., Miller, A. M., McInnes, I. B. and Liew, F. Y. (2009) Animal models of rheumatoid arthritis. European Journal of Immunology, 39(8), pp. 2040-2044. (doi:10.1002/eji.200939578) (PMID:19672892)

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Publisher's URL: http://dx.doi.org/10.1002/eji.200939578

Abstract

Animal models have been used extensively in studies of rheumatoid arthritis pathogenesis. Despite the inherent limitations of all animal models, several rodent models have significantly progressed our understanding of the fundamental mechanisms underpinning rheumatoid arthritis and contributed to several current major advances in treatment. These models include the induced arthritis models such as collagen-induced arthritis, collagen-antibody-induced arthritis, zymosan-induced arthritis, and the methylated BSA model, and the genetically manipulated or spontaneous arthritis models such as the TNF-α-transgenic mouse, K/BxN mouse, and the Skg mouse. Here, we describe these animal models and discuss their advantages and limitations.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Liew, Professor Foo and McInnes, Professor Iain and Asquith, Dr Darren and Miller, Dr Ashley
Authors: Asquith, D. L., Miller, A. M., McInnes, I. B., and Liew, F. Y.
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:European Journal of Immunology
Journal Abbr.:Eur. J. Immunol.
Publisher:Wiley-VCH Verlag
ISSN:0014-2980
ISSN (Online):1521-4141
Published Online:11 August 2009

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
380241Toll-like receptors on T cellsFoo LiewMedical Research Council (MRC)G9818261Infection Immunity and Inflammation Medicine